Neuronal Specification and Connectivity in the Peripheral Nervous System
The lab is interested in understanding the molecular principles underlying the neuronal specification and neural circuit formation in the peripheral nervous system. More specifically, we propose to dissect anatomically and molecularly the construction of the tridimensional structure of the neural networks that underlie the locomotor behavior and hearing process and to reveal the physiological functions of still enigmatic neuronal populations in the cochlear system. In addition, we propose to shed light onto how developmental processes make use of either stochastic or predetermined molecular mechanisms or both simultaneously during the formation of the nervous system.
The research projects in the laboratory employ an integrated approach involving molecular and cell biology, advanced genomics, genetic strategies in the mouse, complemented by anatomical and biochemical methods, enabling in vitro and in vivo analyses of signaling events and molecular mechanisms involved in neuronal fate decision.
From left to right:
- Sensory epithelium of a P3 mouse cochlea
- Innervation of a E14.5 mouse forelimb
- Genetic tracing in a perinatal mouse dorsal root ganglion
A local source of FGF initiates development of the unmyelinated lineage of sensory neurons.
J. Neurosci. 2013 Nov;33(45):17656-66
The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification.
EMBO J. 2013 May;32(11):1613-25
Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells.
Nat Commun 2013 ;4():1438
Positional differences of axon growth rates between sensory neurons encoded by Runx3.
EMBO J. 2012 Sep;31(18):3718-29
Molecular interactions underlying the specification of sensory neurons.
Trends Neurosci. 2012 Jun;35(6):373-81
Saida Hadjab - Senior research fellow
Francois Lallemend - Senior research fellow
Charles Petitpre - Graduate student
Yiqiao Wang - PhD student
Haohao Wu, PhD student
Yongtao Xue-Franzén, Senior lab manager
Anil Sharma, Postdoc
Interested in joining the lab?
Projects for undergraduate students may be available in the lab. Applications for post-doc or PhD positions are very welcomed if the applicant can bring financing. Otherwise early contacts are encouraged to plan applications for external personal grants. In particular candidates with experience in developmental neurobiology or in molecular biology. Send application to firstname.lastname@example.org.