Josephson Laboratory


Anna Josephson

Phone: +46-(0)8-524 870 72
Organizational unit: Department of Neuroscience (Neuro), C4

Research focus

Our group is associated with the Lars Olson group where we mainly focus on the role of the Nogo nerve growth inhibitory system in:

  1. Spinal cord injury, where we aim to obtain post-injury protection and methods of reparation;
  2. CNS plasticity, memory, aging and repair: we have recent data to suggest a key role for the Nogo receptor in the formation of life-long memories;
  3. The development of Alzheimer’s disease where we study the role of the Nogo system in the formation of amyloidal plaque. The aims of our studies are to advance the understanding of the Nogo signaling system in health and disease focusing on gene activity regulation and behavioral indications.

Selected publications

Secretagogin is expressed in sensory CGRP neurons and in spinal cord of mouse and complements other calcium-binding proteins, with a note on rat and human.
Shi T, Xiang Q, Zhang M, Tortoriello G, Hammarberg H, Mulder J, et al
Mol Pain 2012 Oct;8():80

Neuronal overexpression of Nogo receptor 1 in APPswe/PSEN1(ΔE9) mice impairs spatial cognition tasks without influencing plaque formation.
Karlsson T, Karlén A, Olson L, Josephson A
J. Alzheimers Dis. 2013 ;33(1):145-55

FGF1 containing biodegradable device with peripheral nerve grafts induces corticospinal tract regeneration and motor evoked potentials after spinal cord resection.
Nordblom J, Persson J, Aberg J, Blom H, Engqvist H, Brismar H, et al
Restor. Neurol. Neurosci. 2012 ;30(2):91-102

Nogo receptor 1 regulates formation of lasting memories.
Karlén A, Karlsson T, Mattsson A, Lundströmer K, Codeluppi S, Pham T, et al
Proc. Natl. Acad. Sci. U.S.A. 2009 Dec;106(48):20476-81