Top Publications 2016

A global genetic interaction network maps a wiring diagram of cellular function
M. Costanzo, B. VanderSluis, E. N. Koch, A. Baryshnikova, C. Pons, G. Tan, W. Wang, M. Usaj, J. Hanchard, S. D. Lee, V. Pelechano, E. B. et al
Science, 2016; 353 (6306): aaf1420 DOI: 10.1126/science.aaf1420

Pericyte-fibroblast transition promotes tumor growth and metastasis.
Hosaka K, Yang Y, Seki T, Fischer C, Dubey O, Fredlund E, et al
Proc. Natl. Acad. Sci. U.S.A. 2016 Sep;113(38):E5618-27

Development of drug-loaded immunoliposomes for the selective targeting and elimination of rosetting Plasmodium falciparum-infected red blood cells.
Moles E, Moll K, Ch'ng J, Parini P, Wahlgren M, Fernàndez-Busquets X
J Control Release 2016 Nov;241():57-67

Discontinuation of anti-VEGF cancer therapy promotes metastasis through a liver revascularization mechanism.
Yang Y, Zhang Y, Iwamoto H, Hosaka K, Seki T, Andersson P, et al
Nat Commun 2016 Sep;7():12680

Streptococcus pneumoniae senses a human-like sialic acid profile via the response regulator CiaR
Karina Hentrich, Jonas Lofling, Anuj Pathak, Victor Nizet, Ajit Varki, Birgitta Henriques-Normark
Cell Host & Microbe, online 1 September 2016, DOI:

Thermoregulation of Meningococcal fHbp, an Important Virulence Factor and Vaccine Antigen, Is Mediated by Anti-ribosomal Binding Site Sequences in the Open Reading Frame.
Loh E, Lavender H, Tan F, Tracy A, Tang C
PLoS Pathog. 2016 Aug;12(8):e1005794

BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis.
Parsa R, Lund H, Georgoudaki A, Zhang X, Ortlieb Guerreiro-Cacais A, Grommisch D, et al
J. Exp. Med. 2016 Jul;213(8):1537-53

Eradication of Helicobacter pylori and Gastric Cancer: A Systematic Review and Meta-analysis of Cohort Studies.
Doorakkers E, Lagergren J, Engstrand L, Brusselaers N
J. Natl. Cancer Inst. 2016 Sep;108(9):

Endothelial PDGF-CC regulates angiogenesis-dependent thermogenesis in beige fat.
Seki T, Hosaka K, Lim S, Fischer C, Honek J, Yang Y, et al
Nat Commun 2016 Aug;7():12152

Estrogen Receptor α Promotes Breast Cancer by Reprogramming Choline Metabolism.
Jia M, Andreassen T, Jensen L, Bathen T, Sinha I, Gao H, et al
Cancer Res. 2016 Oct;76(19):5634-5646

Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters.
Chen Y, Pai A, Herudek J, Lubas M, Meola N, Järvelin A, et al
Nat. Genet. 2016 Sep;48(9):984-94

Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.
Baptista M, Keszei M, Oliveira M, Sunahara K, Andersson J, Dahlberg C, et al
Nat Commun 2016 Jul;7():12175

Population-based resistance of Mycobacterium tuberculosis isolates to pyrazinamide and fluoroquinolones: results from a multicountry surveillance project.
Zignol M, Dean A, Alikhanova N, Andres S, Cabibbe A, Cirillo D, et al
Lancet Infect Dis 2016 Oct;16(10):1185-92

Regulation of Nuclear Hormone Receptors by MYCN-Driven miRNAs Impacts Neural Differentiation and Survival in Neuroblastoma Patients.
Ribeiro D, Klarqvist M, Westermark U, Oliynyk G, Dzieran J, Kock A, et al
Cell Rep 2016 Jul;16(4):979-93

Structure and mechanism of a molecular rheostat, an RNA thermometer that modulates immune evasion by Neisseria meningitidis.
Barnwal R, Loh E, Godin K, Yip J, Lavender H, Tang C, et al
Nucleic Acids Res. 2016 Jul;():

Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA.
Iovino F, Hammarlöf D, Garriss G, Brovall S, Nannapaneni P, Henriques-Normark B
J. Clin. Invest. 2016 Aug;126(8):2821-6

Functional interplay between MSL1 and CDK7 controls RNA polymerase II Ser5 phosphorylation.
Chlamydas S, Holz H, Samata M, Chelmicki T, Georgiev P, Pelechano V, et al
Nat. Struct. Mol. Biol. 2016 Jun;23(6):580-9

Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis.
Georgoudaki A, Prokopec K, Boura V, Hellqvist E, Sohn S, Östling J, et al
Cell Rep 2016 May;15(9):2000-11

The Endurance of Microbiology: An Interview with Mike Jetten, Mark Martin, Ute Römling, and Victor Torres.
Jetten M, Martin M, Römling U, Torres V
Trends Microbiol. 2016 May;24(5):319-23

Codon-Driven Translational Efficiency Is Stable across Diverse Mammalian Cell States.
Rudolph K, Schmitt B, Villar D, White R, Marioni J, Kutter C, et al
PLoS Genet. 2016 May;12(5):e1006024

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages.
Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, et al
Nat Commun 2016 May;7():11385

The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate.
Chang Z, Jiang N, Zhang Y, Lu H, Yin J, Wahlgren M, et al
Nat Commun 2016 May;7():11537

Escherichia coli: an old friend with new tidings.
Vila J, Sáez-López E, Johnson J, Römling U, Dobrindt U, Cantón R, et al
FEMS Microbiol. Rev. 2016 Mar;():

The Typhoid Toxin Promotes Host Survival and the Establishment of a Persistent Asymptomatic Infection.
Del Bel Belluz L, Guidi R, Pateras I, Levi L, Mihaljevic B, Rouf S, et al
PLoS Pathog. 2016 Apr;12(4):e1005528

Proactive for invasion: Reuse of matrix metalloproteinase for structural memory.
Gucciardo E, Mobashir M, Lehti K
J. Cell Biol. 2016 Apr;213(1):11-3

Dynamics inside the cancer cell attractor reveal cell heterogeneity, limits of stability, and escape.
Li Q, Wennborg A, Aurell E, Dekel E, Zou J, Xu Y, et al
Proc. Natl. Acad. Sci. U.S.A. 2016 Mar;113(10):2672-7

Endocrine vasculatures are preferable targets of an antitumor ineffective low dose of anti-VEGF therapy.
Zhang Y, Yang Y, Hosaka K, Huang G, Zang J, Chen F, et al
Proc. Natl. Acad. Sci. U.S.A. 2016 Apr;113(15):4158-63

Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.
Carmona G, Perera U, Gillett C, Naba A, Law A, Sharma V, et al
Oncogene 2016 Sep;35(39):5155-69

MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis.
Wong H, Jin G, Cao R, Zhang S, Cao Y, Zhou Z
Nat Commun 2016 Mar;7():10824

Transmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europe.
Hofstra L, Sauvageot N, Albert J, Alexiev I, Garcia F, Struck D, et al
Clin. Infect. Dis. 2016 Mar;62(5):655-63

G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.
Kedersha N, Panas M, Achorn C, Lyons S, Tisdale S, Hickman T, et al
J. Cell Biol. 2016 Mar;212(7):845-60

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression.
Feinberg A, Koldobskiy M, Göndör A
Nat. Rev. Genet. 2016 May;17(5):284-99

Nitric Oxide Protects against Infection-Induced Neuroinflammation by Preserving the Stability of the Blood-Brain Barrier.
Olivera G, Ren X, Vodnala S, Lu J, Coppo L, Leepiyasakulchai C, et al
PLoS Pathog. 2016 Feb;12(2):e1005442

Genome-wide quantification of 5'-phosphorylated mRNA degradation intermediates for analysis of ribosome dynamics.
Pelechano V, Wei W, Steinmetz L
Nat Protoc 2016 Feb;11(2):359-76

How Does Streptococcus pneumoniae Invade the Brain?
Iovino F, Seinen J, Henriques-Normark B, van Dijl J
Trends Microbiol. 2016 Apr;24(4):307-15

Effects of PCV7 and PCV13 on invasive pneumococcal disease and carriage in Stockholm, Sweden.
Galanis I, Lindstrand A, Darenberg J, Browall S, Nannapaneni P, Sjöström K, et al
Eur. Respir. J. 2016 Apr;47(4):1208-18

The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis.
Li S, Fell S, Surova O, Smedler E, Wallis K, Chen Z, et al
Dev. Cell 2016 Jan;36(2):164-78

H1N1 influenza virus induces narcolepsy-like sleep disruption and targets sleep-wake regulatory neurons in mice.
Tesoriero C, Codita A, Zhang M, Cherninsky A, Karlsson H, Grassi-Zucconi G, et al
Proc. Natl. Acad. Sci. U.S.A. 2016 Jan;113(3):E368-77

The 5300-year-old Helicobacter pylori genome of the Iceman.
Maixner F, Krause-Kyora B, Turaev D, Herbig A, Hoopmann M, Hallows J, et al
Science 2016 Jan;351(6269):162-5

Architecture of Human IgM in Complex with P. falciparum Erythrocyte Membrane Protein 1.
Akhouri R, Goel S, Furusho H, Skoglund U, Wahlgren M
Cell Rep 2016 Feb;14(4):723-36

Apoptotic cell responses in the splenic marginal zone: a paradigm for immunologic reactions to apoptotic antigens with implications for autoimmunity.
McGaha T, Karlsson M
Immunol. Rev. 2016 Jan;269(1):26-43

Top publications 2015