Satish Srinivas Kitambi Project
Our laboratory has broad interests in understanding cellular features that are unique to different cell types. We use chemical biology and functional genomic tools on cell culture, zebrafish and mouse models to facilitate an improved comprehension of these features. We believe that this approach would facilitate the development of therapies for a broad range of diseases including cancer.
In addition, we actively seek opportunities to develop new technologies to aid our ongoing research.
We believe that our fundamental interest in biology motivated by curiosity will be key to address the societal challenges of tomorrow.
Understanding cytoskeleton regulators in glioblastoma multiforme for therapy design.
Drug Des Devel Ther ;10():2881-2897
The Oncolytic Efficacy and in Vivo Pharmacokinetics of [2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol (Vacquinol-1) Are Governed by Distinct Stereochemical Features.
J. Med. Chem. 2016 Sep;59(18):8577-92
Cholestenoic acids regulate motor neuron survival via liver X receptors.
J. Clin. Invest. 2014 Nov;124(11):4829-42
Vulnerability of glioblastoma cells to catastrophic vacuolization and death induced by a small molecule.
Cell 2014 Apr;157(2):313-328
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis.
Nat. Chem. Biol. 2013 Feb;9(2):126-33
Tetrahydroquinoline-derived macrocyclic toolbox: the discovery of antiangiogenesis agents in zebrafish assay.
ACS Med Chem Lett 2013 Jul;4(7):666-70
Macrocyclic glycohybrid toolbox identifies novel antiangiogenesis agents from zebrafish assay.
Org. Lett. 2013 Feb;15(3):432-5