Research Areas

Research at MTC covers the areas Virology, Bacteriology, Parasitology, Immunology and Tumor Biology.

The research interests are centered on the genetics and molecular biology of virus, bacteria and parasite replication, the role of gene products in abnormal cell growth, the use of microbes as probes for the study of signal transduction, transcription, translation, cell cycle regulation, cell differentiation, and cell death. Specific research areas include the biochemical mechanisms of cell growth control, transformation, signal transduction, and transcriptional regulation, the molecular genetics, molecular biology and molecular pathogenesis of latent, persistent and cytolytic infections, the characterization of receptor interactions and the mechanisms of cell entry, the interaction with cells involved in innate and adaptive immune responses, the pathogenesis of infection and rational drug design.

Cancer, Tumor Biology

This area is focusing on basic mechanisms in causation of tumors and tumor progression, including host responses to tumor development. It includes genetic factors and their protein products, such as oncogenes, cell cycle regulating genes, signal transduction genes, growth factors, apoptosis and cell ageing controls, and suppressor genes and susceptibility genes.

This area also includes studies on genetic cancer susceptibility and familiar cancers, related molecular epidemiology, on the interplay between malignant and normal cells, cell adhesion, angiogenesis, metastasis formation, aspects on tumor regression, and research on the relationship between infections and tumor development, as well as related bioinformatics and biomcomplexity.

The application of this knowledge in the development on experimental treatments, such as gene and immunotherapy, and preventive measures is also included in this area of research.

Research at MTC is carried out in several scientific areas which generates a diversified environment where crossfertilization between different fields has the potential to generate novel and groundbreaking concepts.

These research groups are active in the field of Tumor Biology:

Pontus Aspenström

Cell migration, cell growth and tumour progression.  

Yihai Cao

Cancer and metastasis, Angiogenesis and obesity, Cardiovascular disease, Retinopathy  

Barbro Ehlin-Henriksson Project

Establishment of Epstein-Barr virus latency and characterization of the EBV-associated tumor Burkitts lymphoma (BL)

 

Ingemar Ernberg

Tumor Biology, Epstein-Barr virus (EBV)      

Anita Göndör

DNA repair and chromosome crosstalk: a two-way relationship

     

Marie Arsenian Henriksson

Approaches to target the MYC oncoprotein to combat cancer

     
Elena Kashuba

EBNA-binding cellular proteins and their role in cell transformation

     
Satish Srinivas Kitambi Project Understanding cellular features that are unique to different cell types      
Eva Klein

Interaction of Epstein Barr Virus (EBV) with B lymphocytes

     
Georg Klein Epstein Barr virus (EBV), oncogenes, and tumor suppressor genes      

Sonia Lain

Discovery and elucidation of the mechanisms of action of tumour selective compounds
 
   
 Lars-Gunnar Larsson Myc oncogenes      

Rolf Ohlsson

Epigenetics, Cell and tumour biology      
 Galina Selivanova Development of small molecules restoring the tumor suppression functions of p53      
Margareta Wilhelm

Exploring the role of p73 isoforms during tumor development

     
Joanna Zawacka-Pankau

Therapeutic potential of activation of p53 family members to treat cancer.

     
Giovanna Zinzalla

Chemistry To Understand and Manipulate Master Regulators of Transcription

     

 

Biomedical Ecology 

Biomedical ecology involves basal bacteriology, immunology, studies on metabolism, mucous membrane biology, antimicrobial therapy, pathogenesis with special reference to clinical ecological questions, the stability and dynamics of the normal flora, biofilm formation of members of the normal flora as well as pathogens and the cross-talk between the microbial flora and host tissue.

Biofilm formation, the ability of the microflora to build up multicellular structures on abiotic surfaces, in secretion fluids or on host tissue alters microbial physiology and the interaction between the microbe and the host.

These research groups are active in the field of Biomedical Ecology:

Ingemar Ernberg

Tumor Biology, Epstein-Barr virus (EBV)      
Elisabeth Norin

Faecal transplant against Clostridium difficile diarrhoea

     

Sven Pettersson

Regulation of gut homeostasis

     

Ute Römling

Multicellular behavior in Enterobacteriaceae, Pseudomonas aeruginosa infections in cystic fibrosis

     

 

Immunology 

The following groups are active in the field of Immunology:

Jan Albert

HIV genetic variation, evolution and resistance  

Francesca Chiodi

Mechanism of B and T cell death during HIV infection

 
Gunilla Karlsson Hedestam

Infection Immunology

     
Mikael Karlsson

B cell biology team

     

Klas Kärre

NK cell recognition      
 Peter Liljeström

Vaccines and Immunity

     

Sven Pettersson

Regulation of gut homeostasis

     

Antonio Rothfuchs

DC-T cell engagements during BCG vaccination

     
Martin  Rottenberg &
Hans Wigzell
Intracellular Mycobacterium tuberculosis      
Lisa Westerberg Understanding the Immune system by studying Immunodeficiency Diseases      
  Björn Önfelt  Natural Killer cells (NK cells) and T-cells      

 

Infection 

Research in Bacteriology, Parasitology and Virology is conducted at MTC, sometimes under the collective name of "Infection Biology".

Bacteriology

Bacteria are present everywhere in our surroundings. Some bacterial species are beneficial for human health, while others can cause a variety of infectious diseases.

Today's research on the molecular basis of the interaction between bacteria and humans transcends the boundaries between bacteriology, cell biology, and immunology. Collectively, this work will reveal novel concepts for future therapies against bacterial infections.

These research groups are active in the field of Bacteriology:

Annelie Brauner

Innate immunity and E. coli in the urinary tract  

Lars Engstrand

The human intestinal microbiome, Helicobacter pylori and gastrointestinal disease development

The Clinical Genomics facility
     

Ingemar Ernberg

Tumor Biology, Epstein-Barr virus (EBV)      

Jan-Ingmar Flock

Development and assessment of a vaccine against Streptococcus equi

     
Birgitta Henriques & Staffan Normark

Host-pathogen interactions in health and disease

     

Sven Pettersson

Regulation of gut homeostasis

     

Mikael Rhen

Salmonella enterica as a model for intracellular parasitism

     

Ute Römling

Multicellular behavior in Enterobacteriaceae, Pseudomonas aeruginosa infections in cystic fibrosis

     
Åsa Sjöling

Gastroenteric bacterial virulence regulation and transmission mechanisms

     

Velmurugesan Arulampalam

Environmental sensors in the service of immunity and energy metabolism

 

Parasitology 

Parasites are eukaryotic pathogens that can be divided into the ectoparasites (e.g. flies, lice and ticks) and the endoparasites that actually enter the body of the host.

The latter group includes protozoa and worms of different phylogenetic affiliation. The genetic diversity among parasites is enormous and the study of these will reveal new biological concepts as well as improving the medical status of people around the world.

Research groups active in the field of Parasitology

Hannah Akuffo

Leishmania, Parasitology

         

Anders Björkman

Malaria treatment and control  

Francesca Chiodi

Mechanism of B and T cell death during HIV infection

 
Akira Kaneko

Malaria elimination on islands

     
 Mats Wahlgren Malaria Research      

Virology

Viruses are small microbes that carry only very basic genetic information. They need cellular enzymes and proteins for replication. Viruses cause acute and chronic infections and they cause tumors in humans and animals.

The challenge is to identify both the patogen and its pathogenic potential, and to discover means for chemical and immunological treatment. The relatively small genomes lend themselves to sophisticated analysis of disease-inducing and tumorigenic pathways when viral genomes are associated with or integrated into the human genome.

Research groups active in the field of Virology

Jan Albert

HIV genetic variation, evolution and resistance  

Tobias Allander

Clinical Virology and Virus Discovery

 

Francesca Chiodi

Mechanism of B and T cell death during HIV infection

 

Jonathan Coquet

Helper T cells : Generals of the immune response

 

Lars Engstrand

Helicobacter pylori and gastro-duodenal disease      

Lifu Hu

Epigenetic changes in initiation and development of cancers

     
Maria Issagouliantis Naked? DNA vaccines for treatment of chronic viral infections      
Gunilla Karlsson Hedestam

Infection Immunology

     
Eva Klein

Interaction of Epstein Barr Virus (EBV) with B lymphocytes

     
Georg Klein Epstein Barr virus (EBV), oncogenes, and tumor suppressor genes      
Jonas Klingström Project Hantaviruses - why do we get sick when voles don't?      
 Peter Liljeström

Vaccines and Immunity

     
Gerald McInerney

Regulation of Gene Expression during Viral Infection

     

Bence Rethi

The role of Interleukin-7 in T cell - B cell communication, Dendritic cell reprogramming by endogenously produced lactic acid

     
Martin  Rottenberg &
Hans Wigzell
Intracellular Mycobacterium tuberculosis      
 Britta Wahren

An Effective HIV Vaccine

     
ImmunologyTumour BiologyVirology