Jonas Fuxe Group

Senior researcher

Jonas Fuxe

Organizational unit: Jonas Fuxe group
E-mail: jonas.fuxe@ki.se

 

Research Projects

Mechanisms of Tissue Remodeling in Inflammation and Cancer

A fundamental principle of multi-cellular organisms is the ability of cells to interact and communicate. Tubular organs are lined by epithelial and endothelial cells that form selective barriers allowing the formation of different tissue compartments. This function is dependent on the ability of cells to polarize and establish specialized intercellular junctions that regulate flux of ions, solutes and cells across the barrier. The assembly and disassembly of these junctions is tightly regulated during development and in normal physiology, but is disturbed in pathological conditions of tissue remodeling, such as in chronic inflammation and cancer. We use a combination of in vitro studies and mouse models of chronic airway inflammation and cancer to study the role of specific growth factors and cytokines in mediating tissue remodeling and junction reorganization in endothelial and epithelial cell layers.

A major research theme in the lab is remodeling of blood and lymphatic vessels. While VEGF is a major angiogenic factor, less is known about the mechanisms that drive other types of vascular remodeling including phenotypic switches of endothelial cells leading to excessive infiltration of inflammatory cells. We are particularly interested in the role of angiopoietins and the Tie2 signaling pathway in modulating the inflammatory response by acting on blood and lymphatic vessels.

Another theme is the role of epithelial-mesenchymal transition (EMT) in tumor cell invasion and epithelial remodeling in chronic inflammation. EMT is characterized by loss of cell-cell adhesion and polarity accompanied by cytoskeletal rearrangements and increased cell motility. TGF-b is a major inducer of EMT but the molecular mechanisms involved are not clear. We are interested in transcriptional regulation of target genes downstream of the TGF-b/Smad signaling pathway.

Group Members

Azadeh NilchianPhD student
Jonas FuxeSenior researcher
Nikolina GiotopoulouR&D trainee, Graduate Student

 

Postdoc: Vacant position(s)

Alumni:

Mei-Fong Pang, PhD. PhD student in Fuxe group 2009-2012. Current position: postdoc at Princeton University, US.

Jill Johnson, PhD. Postdoc in Fuxe group 2008-2011. Current position: Research Fellow at the National Heart and Lung Institute, Imperial College London

Tove Berg, PhD. Postdoc in Fuxe group 2009-2012. 

Vedrana Tabor, PhD. Postdoc in Fuxe group 2012-2014. 

Sandra Travica, PhD. Postdoc in Fuxe group 2013-2014. Current position: Medical Scientific Advisor for Oncology Business at Pfizer Inc. 

 

Publications

2016

Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis.
Georgoudaki A, Prokopec K, Boura V, Hellqvist E, Sohn S, Östling J, et al
Cell Rep 2016 May;15(9):2000-11

[Clinical study of an antimitotic antibiotic: rufochromomycin (R.P. 5,278). On 166 cases. Value in malignant reticulopathies].
Chauvergne J, Biraben J, Lagarde C, Hugues A
Bull Cancer ;53(2):229-46

TGF-β1-Induced Epithelial-Mesenchymal Transition Promotes Monocyte/Macrophage Properties in Breast Cancer Cells.
Johansson J, Tabor V, Wikell A, Jalkanen S, Fuxe J
Front Oncol 2015 ;5():3

2015

Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma.
Johnson J, Folestad E, Rowley J, Noll E, Walker S, Lloyd C, et al
Am. J. Physiol. Lung Cell Mol. Physiol. 2015 Apr;308(7):L658-71

2014

Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain.
Arnold T, Niaudet C, Pang M, Siegenthaler J, Gaengel K, Jung B, et al
Development 2014 Dec;141(23):4489-99

C/EBPβ expression is an independent predictor of overall survival in breast cancer patients by MHCII/CD4-dependent mechanism of metastasis formation.
Kurzejamska E, Johansson J, Jirström K, Prakash V, Ananthaseshan S, Boon L, et al
Oncogenesis 2014 ;3():e125

TGF-β-induced epithelial-mesenchymal transition: a link between cancer and inflammation.
Fuxe J, Karlsson M
Semin. Cancer Biol. 2012 Oct;22(5-6):455-61

 

Book chapter in “CANCER AND INFLAMMATION MECHANISMS: Chemical, Biological, and Clinical Aspects”. 2014 p23-39 (Wiley).

 

 

2013

MiR-155-mediated loss of C/EBPβ shifts the TGF-β response from growth inhibition to epithelial-mesenchymal transition, invasion and metastasis in breast cancer.
Johansson J, Berg T, Kurzejamska E, Pang M, Tabor V, Jansson M, et al
Oncogene 2013 Dec;32(50):5614-24

Human enterovirus species B in ileocecal Crohn's disease.
Nyström N, Berg T, Lundin E, Skog O, Hansson I, Frisk G, et al
Clin Transl Gastroenterol 2013 ;4():e38

Deficiency for endoglin in tumor vasculature weakens the endothelial barrier to metastatic dissemination.
Anderberg C, Cunha S, Zhai Z, Cortez E, Pardali E, Johnson J, et al
J. Exp. Med. 2013 Mar;210(3):563-79

2012

TGF-β-induced epithelial-mesenchymal transition: a link between cancer and inflammation.
Fuxe J, Karlsson M
Semin. Cancer Biol. 2012 Oct;22(5-6):455-61

The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2.
Gaengel K, Niaudet C, Hagikura K, Laviña B, Siemsen B, Muhl L, et al
Dev. Cell 2012 Sep;23(3):587-99

Repeated cisplatin treatment can lead to a multiresistant tumor cell population with stem cell features and sensitivity to 3-bromopyruvate.
Wintzell M, Löfstedt L, Johansson J, Pedersen A, Fuxe J, Shoshan M
Cancer Biol. Ther. 2012 Dec;13(14):1454-62

Essential role of the coxsackie- and adenovirus receptor (CAR) in development of the lymphatic system in mice.
Mirza M, Pang M, Zaini M, Haiko P, Tammela T, Alitalo K, et al
PLoS ONE 2012 ;7(5):e37523

EMT research – not an empty promise

Fuxe J.

International Innovation, NordicFocus, September 2012;27-33

Earlier publications

Jonas Fuxe publications 2002-2011