Pancreatic Islet Plasticity

The insulin secreting beta cells within the pancreatic islets have the potential to adapt to various physiological circumstances. An increased demand for insulin due for example to obesity, pregnancy, or beta cell loss can lead to an increased beta cell mass. Alternatively, functional changes in individual beta cells can provide an overall increase in glucose-stimulated insulin release in case of increased demand. This project aims at investigating the cellular triggering mechanisms regulating islet mass and function, by the combined use of in vitro methodologies and in vivo imaging approaches.

Project leader

Senior researcher

Erwin Ilegems

Organizational unit: Signal Transduction
E-mail: Erwin.Ilegems@ki.se

People working on Pancreatic Islet Plasticity

Senior lab manager

Andrea Dicker

Phone: +46-(0)8-517 794 55
Organizational unit: Signal Transduction
E-mail: Andrea.Dicker@ki.se

Assistant professor

Anna Voznesenskaya

E-mail: anna.voznesenskaya@ki.se

Graduate Student

Pim van Krieken

Organizational unit: Signal Transduction
E-mail: pim.van.krieken@ki.se