The Lung and Rheumatic diseases
The etiology of rheumatoid arthritis (RA) is only partly understood, but exposures causing inflammation in the lungs such as cigarette smoke, silica dust and traffic pollution have been associated with an increased risk of RA.
We are currently exploring the hypothesis that inflammatory airway diseases may initiate the development of RA with a specific focus on the RA phenotypes defined by presence or absence of citrullinated antibodies. We use a case-control approach on the EIRA incident RA case-control study and link data to national patient and prescription registers.
The program is conducted in collaboration between the Respiratory Medicine and Clinical Epidemiology unit at the Department of Medicine Solna, the Institute for Environmental Medicine and AstraZeneca R&D.