Rheumatology Research

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foto Eva Jemseby

Rheumatology is the field of research, education and care for diseases that affect the musculoskeletal system. These diseases are very common, and comprise both inflammatory disorders such as arthritis, myositis, systemic lupus erythematosus (SLE), Sjögren's syndrome etc, and non-inflammatory disorders such as osteoarthritis.

Within the rheumatology field at Karolinska we are carrying out extensive research on the etiology, molecular pathogenesis, therapy and outcomes in several of the most severe chronic rheumatic inflammatory conditions such as rheumatoid arthritis, myositis, Sjögren´s syndrome and systemic lupus erythematosus (SLE). The research is translational with several groups of independent but collaborating researchers working in our unit towards a common goal.

Our strategy is to take advantage of the unique and large patient groups that we can follow over time in our clinic, and benefit from the contribution from patients in this research. This clinical outcome and therapy-based research is combined with extensive biomedical and experimental animal research performed in our laboratory at the nearby Center for Molecular Medicine (CMM). Here, several groups are engaged in studies on molecular pathogenesis as well as in the development and validation of new therapies for inflammatory diseases.

n addition we have an active clinical trials unit that performs both academic clinical trials, observational studies on outcome of new interventions and randomized controlled studies in collaboration with pharmaceutical companies and other groups in the world. We also have an active epidemiological section which takes advantage of the possibilities to study the long term effects of the diseases and of therapies in Sweden. This is critical for our efforts to understand the etiology and provide cures for the various rheumatic diseases.

We have established extensive international networks, where typically members from 10-15 nations are active in our clinic and research groups. We are involved in a number of international as well as national networks for rheumatology and immunology research (e.g. COMBINE), including coordination of a major EU-funded integrated project (AutoCure).

Research areas

Research group Lars Klareskog

Researcher Research area
Caroline Grönwall Autoantibody repertoires in inflammatory and autoimmune disease
Fredrik Wermeling

Autoimmune and inflammatory diseases – novel treatment strategies

Karin Lundberg

The Pathobiology of Autoantibodies in Rheumatoid Arthritis

Jon Lampa

Neuro-immune regulation and central nervous impact on rheumatic diseases