Research group Kristina Broliden
Kristina Broliden, Professor, Group Leader
Professor and Senior Consultant, Unit of Infectious Diseases, Karolinska Institutet and Clinic of Infectious Diseases, Karolinska University Hospital
Head of Department, Department of Medicine Solna, Karolinska Institutet
Carl Aust, Doctoral student
Frideborg Bradley,Doctoral student
Adam Burgener, Rerearcher, associated
Gabriella Edfeldt, Doctoral student
Mariethe Ehnlund, BMA
Anna Gibbs, Postdoc
Gökçe Günaydın, Postdoc
|Taha Hirbod, Docent, associated|
|Andrea Introini, Postdoc|
|Anna Lindblom, Postdoc, associated|
|Maria Röhl, Doctoral student|
|Martina Söderman, Doctoral student|
|Annelie Tjernlund, Research Assistant|
|Thomas Tolfvenstam, Researcher, associated|
|Lars Öhrmalm, Resident physician, Postdoc|
|Anne Rasikari, Administrator|
GENITAL MUCOSAL BARRIERS AGAINST HIV-INFECTION
The HIV epidemic is still increasing globally and the search for effective biomedical HIV prevention options is intense. There are enormous intraindividual variations that exist in HIV/AIDS susceptibility. Environmental factors including hormonal contraceptive use, genital infections and sexual intercourse affect the susceptibility to HIV infection as demonstrated in epidemiological and experimental studies. The molecular mechanisms behind these findings are however poorly defined. Our group aims to study how the human female genital tract is affected by these factors by assessing tissue samples and cervicovaginal secretions from large cohorts of Swedish and Kenyan women who are sexually exposed to HIV infection. Genital samples are defined by expression of junction proteins, distribution and density of HIV receptors and innate immune proteins by using immunohistochemistry, tissue explants models and proteomics. By exploring some of the underlying mechanisms for a dysfunctional mucosal barrier we hope to contribute to the development of topical prophylactic compounds and to the prescription of optimal contraceptive methods to women.
Depot Medroxyprogesterone Acetate Use Is Associated With Elevated Innate Immune Effector Molecules in Cervicovaginal Secretions of HIV-1-Uninfected Women.
J. Acquir. Immune Defic. Syndr. 2015 May;69(1):1-10
Respiratory viruses associated with community-acquired pneumonia in children: matched case-control study.
Thorax 2015 Sep;70(9):847-53
Improving Adherence to Post-Cervical Biopsy Sexual Abstinence in Kenyan Female Sex Workers.
Am. J. Reprod. Immunol. 2016 Jul;76(1):82-93
Clinical utility of PCR for common viruses in acute respiratory illness.
Pediatrics 2014 Mar;133(3):e538-45
Presence of CD8+ T cells in the ectocervical mucosa correlates with genital viral shedding in HIV-infected women despite a low prevalence of HIV RNA-expressing cells in the tissue.
J. Immunol. 2014 Apr;192(8):3947-57
A comparative proteomic analysis of the soluble immune factor environment of rectal and oral mucosa.
PLoS ONE 2014 ;9(6):e100820
Expression profiles of antimicrobial peptides in the genital tract of women using progesterone intrauterine devices versus combined oral contraceptives.
Am. J. Reprod. Immunol. 2014 Nov;72(5):475-84
HIV acquisition is associated with increased antimicrobial peptides and reduced HIV neutralizing IgA in the foreskin prepuce of uncircumcised men.
PLoS Pathog. 2014 Oct;10(10):e1004416
HIV Infection in Uncircumcised Men Is Associated With Altered CD8 T-cell Function But Normal CD4 T-cell Numbers in the Foreskin.
J. Infect. Dis. 2014 Apr;209(8):1185-94
Immune correlates of HIV exposure without infection in foreskins of men from Rakai, Uganda.
Mucosal Immunol 2014 May;7(3):634-44
The role of serpin and cystatin antiproteases in mucosal innate immunity and their defense against HIV.
Am. J. Reprod. Immunol. 2014 Jan;71(1):12-23
A systems biology examination of the human female genital tract shows compartmentalization of immune factor expression.
J. Virol. 2013 May;87(9):5141-50
Decreased functional T lymphocyte-mediated cytokine responses in patients with chemotherapy-induced neutropenia.
J. Intern. Med. 2013 Oct;274(4):363-70
Stable CD4 expression and local immune activation in the ectocervical mucosa of HIV-infected women.
J. Immunol. 2013 Oct;191(7):3948-54
Adress:Institutionen för medicin, Solna (MedS), K2