Arthritis research team - Anca Catrina
We are a mixed team of basic and clinical scientists performing translational research in the field of rheumatology with a special focus on rheumatoid arthritis. Using a large array of molecular techniques and having access to national registries and clinical samples we are currently exploring the early pathogenic events leading to chronic joint disease. We focus on understanding how interactions between genes and environment lead first to pathogenic events outside the joint (such as in the lungs and the immune system) and only in a second step to local joint inflammation. We also investigate how hypoxia and antibodies contribute to propagation of chronic joint inflammation and bone destruction.
Anca Catrina, MD, PhD, group leader
Heidi Wähämaa, PhD, lab coordinator
Meng Sun, PhD
Erik af Klint, MD, PhD
Petra Neregård, MD, PhD
Marianne Engström, Research Engineer
Aase Eline Haj Hensvold, MD, PhD Student
Gudrun Reynisdottir, MD, PhD Student
Akilan Krishnamurthy, MSc, PhD Student
Vijay Joshua Balasingh, MSc, PhD Student
Pingling Zeng, MSc, PhD Student
Karin Lundvall, Research Nurs
Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins.
Ann. Rheum. Dis. 2015 Feb;74(2):375-80
Dendritic cell reprogramming by endogenously produced lactic acid.
J. Immunol. 2013 Sep;191(6):3090-9
The cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and rats.
Ann. Rheum. Dis. 2013 Jul;72(7):1239-48
Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition.
J. Exp. Med. 2013 Mar;210(3):445-55
Local administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritis.
Arthritis Res. Ther. 2012 Jan;14(1):R20
Lancet 2009 Feb;373(9664):659-72
Evaluation of arthroscopy and macroscopic scoring.
Arthritis Res. Ther. 2009 ;11(3):R81
Monocytes are essential for inhibition of synovial T-cell glucocorticoid-mediated apoptosis in rheumatoid arthritis.
Arthritis Res. Ther. 2008 ;10(6):R147
Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells.
Ann. Rheum. Dis. 2008 Oct;67(10):1488-92
Intraarticular corticosteroids decrease synovial RANKL expression in inflammatory arthritis.
Arthritis Rheum. 2006 May;54(5):1463-72
Petra Neregård, 2013
Link to thesis: http://hdl.handle.net/10616/41368
Shankar Revu, 2012
Link to thesis: http://hdl.handle.net/10616/41118
Dimitris Makrygiannakis, 2008
Link to thesis: http://hdl.handle.net/10616/39037