Alf Grandien group
Hematopoietic tumors are characterized by aberrant expression of large number of genes. We try to determine which minimal changes in gene expression that are necessary for tumor formation and also the dependence of these alterations in gene expression for sustained tumor growth. We believe this knowledge will be important for rational drug design.
Using retroviral expression vectors, combinations of tumor-associated genes are expressed in primary hematopoietic cells of various lineages and differentiation stages. Minimal combinations of genes resulting in cellular immortalization and tumor transformation are identified and further characterized. Experiments are performed with cells from various species including mouse and man.
|Alf Grandien, Group Leader, Associate professor (Docent), PhD, l´Université PIERRE et MARIE CURIE (Paris 6), 1992, Dr Med Sc, Uppsala universitet, 1993|
|Kari Högstrand, PhD, Assistant professor|
|Stephanie Darmanin, PhD, Post-doc (in collaboration with Yenan Bryceson and Hans-Gustaf Ljunggren, Center for Infectious Medicine, Karolinska Institutet)|
|TachaZi ("Chaz") Plym Forshell, PhD, Post-doc|
Hematopoiesis in the thymidine kinase 2 deficient mouse model of mitochondrial DNA depletion syndrome.
J. Inherit. Metab. Dis. 2010 Jun;33(3):231-6
Gene expression profiling of erythroblasts from refractory anaemia with ring sideroblasts (RARS) and effects of G-CSF.
Br. J. Haematol. 2010 Jun;149(6):844-54
Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.
Proc. Natl. Acad. Sci. U.S.A. 2010 Jan;107(1):58-63
DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis.
Oncogene 2009 May;28(18):1949-59
Transmission of Toxoplasma gondii from infected dendritic cells to natural killer cells.
Infect. Immun. 2009 Mar;77(3):970-6
Participation of FLIP, RIP and Bcl-x(L) in Fas-mediated T-cell death.
Scand. J. Immunol. 2007 Oct;66(4):410-21
Leukemia inhibitor factor (LIF) inhibits HIV-1 replication via restriction of stat 3 activation.
AIDS Res. Hum. Retroviruses 2007 Mar;23(3):398-406
Severe defect in thymic development in an insertional mutant mouse model.
J. Immunol. 2007 Apr;178(8):5018-27
Drug-induced death of the asexual blood stages of Plasmodium falciparum occurs without typical signs of apoptosis.
Microbes Infect. 2006 May;8(6):1560-8
Impact of FASL-induced apoptosis in the elimination of tumor cells by NK cells.
Mol. Immunol. 2005 Feb;42(4):495-9