Doctoral course within the doctoral programme in Epidemiology
Course number 2228
Course dates: November 14, 16, 18, 21, 23
After successfully completing this course you as a student are expected to be able to:
- Describe the basic organization of the human genome and the central dogma of eukaryote genetics.
- Relate the concepts of meiosis, recombination, linkage and linkage disequilibrium to each other.
- Draw conclusions about genetic influences from trait distributions in families and estimate the relative degree of genetic influences from twin correlation data.
- Use publically available databases to find positions of genetic markers and to identify suitable tag markers for candidate genes.
- Utilize SNP marker as instrumental variables and polygenic predictors.
Intended learning outcomes are classified according to Bloom's taxonomy: knowledge, comprehension, application, analysis, synthesis, and evaluation (Bloom, 1956, extended by Anderson and Krathwohl, 2001).
Content of the course
The course is about concepts and methods used in studies of genetic variation influencing disease and other phenotypes. It will thoroughly cover basic genetic inheritance and how it influences complex quantitative traits. Modern genediscovery strategies and polygenic methods will be described in theory and practice. The primary focus is on genetic association studies with study design and interpretation/utilization of results. Medelian randomization approaches. Secondary focus will be on the role of de novo mutations and epigenetic mechanisms for complex trait.
Specific entry requirements
Knowledge in epidemiology and biostatistics equivalent to "Epidemiology I: Introduction to epidemiology" (course 1577), "Epidemiology II: Design of epidemiological studies" (course 1622), "Biostatistics I: Introduction for epidemiologists" (course 1579) and "Biostatistics II: Logistic regression for epidemiologists" (course 1513).
Recommended reading: Compendium covering basic genetic concepts will be distributed before the course. Scientific articles and hand-outs distributed during the course.