Talk: Genomic insights into human brain development, evolution and disease
Talk by Arnold Kriegstein, MD, PhD, Department of Neurology, UCSF.
Dr. Kriegstein’s research focuses on the way in which neural stem and progenitor cells in the embryonic brain produce neurons, and ways in which this information can be used for cell based therapies to treat diseases of the nervous system. His lab found that radial glial cells are neuronal stem cells in the developing brain, and also identified a second type of precursor cell produced by radial glial cells that is responsible for generating specific neuronal subtypes. He has recently begun to characterize the progenitor cells within the developing human brain, to determine the genetic profiles of specific progenitor populations, and to explore how these cells contribute to the huge expansion of neuron number that characterizes human cerebral cortex.
Human iPSC-Derived Cerebral Organoids Model Cellular Features of Lissencephaly and Reveal Prolonged Mitosis of Outer Radial Glia.
Cell Stem Cell 2017 Apr;20(4):435-449.e4
Zika virus cell tropism in the developing human brain and inhibition by azithromycin.
Proc. Natl. Acad. Sci. U.S.A. 2016 Dec;113(50):14408-14413
Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas.
Mol. Syst. Biol. 2016 Nov;12(11):889