Lectures and seminars

MBB Seminar: Prof. Andrea Mattevi

2015-12-1814:00 Large seminar room (in A3:3), Scheele laboratory, Scheeles väg 2Campus Solna

Title: On the molecular mechanisms of chromatin modification

Prof. Andrea Mattevi's research involves  the investigation of medically relevant enzymes with interesting chemical properties, such as complex multifunctional systems and proteins performing unusual catalytic functions. The core of the research activity is represented by X-ray crystallography, employed to study protein three-dimensional structures. This is, however, complemented by other approaches such as site-directed mutagenesis, analysis of enzyme kinetics and computational chemistry. He will be presenting his recent research  to reveal the molecular details – mostly in terms of protein/protein and protein/DNA interactions – of the assembly and recognition of Lysine-specific demethylase (LSD1)-CoREST1  in complex with the nucleosome.