Fluid kinetics

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Christer Svensén and his research group studies the effects of cardiovascular monitoring and fluid treatment for patients prior to, during and after surgery. Hydration based on blood pressure and urine production has often led to the patient storing unnecessary fluids, which affects both morbidity and mortality.

Studies are conducted of infusion solutions' distribution in the body during different pathological conditions, and of non-invasive methods to assess a patient's fluid status and hydration in connection with sepsis and septic shock.

Research Group

Anna Augustsén, MD

Jacob Broms, MD

Maria Cronhjort, MD, Graduate Student

Mikael Gellerfors, MD, Graduate Student

Eva Joelsson-Alm, RN, PhD, Supervisor

Mona Britt Divander, RN, Research nurse

Christer Svensén, MD, PhD, Professor and Research group leader

Internal/external networks:

Olof Wall, MD

Audrius Andrijauskas, MD, PhD, Vilnius

Giedrius Kvederas, MD, Vilnius

Ruifeng Zeng, MD, Wenzhou, China

Husong Li, MD, PhD, UTMB Health, Texas

Selected Publications

The use of a noninvasive hemoglobin monitor for determining fluid distribution and elimination in pediatric patients undergoing minor surgery.
Lian Q, Li H, Zeng R, Lang J, Shangguan W, Liu H, Wang B, Rodhe PM, Svensen CH.
J Clin Monit Comput 2015 Feb;29(1):41-6

Evaluation of hydration status calculated from differences in venous and capillary plasma dilution during stepwise crystalloid infusions: A randomized crossover study in healthy volunteers.
Svensen C, Stankevičius E, Broms J, Markevičius V, Andrijauskas A
Medicina (Kaunas) 2014 ;50(5):255-62

The maintenance and monitoring of perioperative blood volume.
Iijima T, Brandstrup B, Rodhe P, Andrijauskas A, Svensen C
Perioper Med (Lond) 2013 May;2(1):9

The use of a noninvasive hemoglobin monitor for volume kinetic analysis in an emergency room setting.
Sjöstrand F, Rodhe P, Berglund E, Lundström N, Svensen C
Anesth. Analg. 2013 Feb;116(2):337-42

Modelling of peripheral fluid accumulation after a crystalloid bolus in female volunteers - a mathematical study.
Rodhe P, Drobin D, Hahn R, Wennberg B, Lindahl C, Sjöstrand F, Svensen CH.
Comput Math Methods Med 2010 Dec;11(4):341-51

Hypoproteinemia does not alter plasma volume expansion in response to a 0.9% saline bolus in awake sheep.
Brauer KI, Brauer LP, Prough DS, Rodhe P, Hahn RG, Traber LD, Svensen CH.
Crit Care Med. 2010 Oct;38(10):2011-5.

Pharmacokinetic aspects of fluid therapy.
Svensen C, Rodhe P, Prough D
Best Pract Res Clin Anaesthesiol 2009 Jun;23(2):213-24


Anesthesiology and Intensive Care