Child and Adolescent Psychiatry - research projects

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Jan-Olov Larsson's group

Attention Deficit Hyperactive Disorder (ADHD) and self perception

More information about this project is available in Swedish

Tobias Edbom, Registered nurse, PhD
Jan-Olov Larsson, MD, PhD, Projekt leader

Projekt group

Paul Lichtenstein, Professor
Mats Granlund, Professor, Högskolan i Jönköping

Adult attention - an MRI twin study

The overall aim of this ongoing project is to highlight brain regions linked to attention problems that are susceptible to environmental factors.

We have identified 15 Monozygotic (MZ) twin pairs discordant for attention and 15 controls from a population-based sample of 20 000 twins (20 to 45-years-old; males and females) that recently completed a self-report questionnaire.

The fMRI paradigm focuses on visual-spatial working memory tasks. These tasks have been demonstrated to engage prefrontal and parietal activity and are suitable for adults (Klingberg, 2002). The clinical part aims to study correlates to the attention problems using the twin-cotwin method. Data collection started in May 2007 and is now finished.

Jan-Olov Larsson, MD, PhD, Projekt leader

Projekt group

Bettina Friedrichs, Post-doc
Torkel Klingberg, Professor, MD, PhD
Henrik Larsson, Post-doc
Gaëlle Leroux, Research engineer, Centre Cyceron, Caen, France
Paul Lichtenstein, Professor, MD, PhD

Children with Asperger syndrome - sleep patterns

More information about this project is available in Swedish

Jan-Olov Larsson, MD, PhD, Projekt leader

Members of the research group

Hiie Allik, MD, PhD
Hans Smedje, MD, PhD, Uppsala University

Adults with Attention Deficit Hyperactive Disorder (ADHD)

More information about this project is available in Swedish

Jan-Olov Larsson, MD, PhD, Projekt leader

Members of the research group

Ylva Holst, psychologist
Håkan Nyman, psychologist, MD, PhD

Contact: Jan-Olov Larsson, Projekt leader


Per-Anders Rydelius group

PTSD - Post Traumatic Stress Disorder

More information about this project is available in Swedish

Atia Daud, Psychologist, PhD
Per-Anders Rydelius, Professor, MD, PhD

Children with Imperforate Anus - psychosocial aspects

Imperforate anus including lack of a normal anorectum is an uncommon malformation.

In general, children with high and intermediate imperforate anus receive a colostomy immediately after birth to empty their bowels. At the age of three months a new anus is constructed surgically. The reconstructed anus must be dilated to attain adequate width, which requires daily dilations for three months after the surgery. Many children with imperforate anus have functional difficulties including constipation and faecal incontinence for several years. Regular enemas are administered as treatment and as preventive treatment

When a child has a chronic condition - imperforate anus -, there may be implications for the psychosocial well-being of the child and the parents as well as influences on family child-parent relationship that in turn might lead to difficulties with peer-relations. These families may need help through consultation and liaison work between the child psychiatric department and the paediatric disciplines.

The overall aim is to explore psychosocial consequences on children with high or intermediate imperforate anus and their parents in order to have a basis for a forthcoming caring program for the family.

The study is a collaboration between the the child and adolescent psychiatric unit and the paediatric surgery unit at Astrid Lindgren Children's hospital, Department of Women's and Children's Health.

Margret Nisell, RN, PhD
Per-Anders Rydelius, Professor, MD, PhD

Child psychiatric patients in adulthood

An overall aim with the study is to describe and discuss the borderland between CAP and GenP especially issues of knowledge and co-operation that can improve co-operation and the psychiatric treatment and care within the two disciplines.

The questions at issue were:

  • What happens to the former CAP patient group?
  • Did they become well functioning adults?
  • Will they be in need of psychiatric care?
  • Who will develop severe mental illness?
  • Will knowledge about them be used for prevention?
  • Who will develop criminality?
  • Is mortality rate higher in this group than in general?
  • Which gender differences occur in question of later adaptation?

A sample of 1400 former Child and Adolescent Psychiatry (CAP) patients has been followed up 12 to 33 years after CAP care through examination of hospital records and linkage to official registers.

Furthermore inpatient hospital care in childhood and adolescence for 176 general psychiatry (GenP) inpatients and outpatients was examined until and including 1999 through examination of hospital files and linkage to official registers.

Questions asked in the study of inpatient hospital care in childhood in a GenP patient group are:

  • Which needs for hospital care was found in this group and was they discriminated from the needs in the Swedish general population?
  • Are there a group of children and adolescents that has been admitted to paediatrics because of somatic symptoms were the needs of psychiatric care have not been observed, that later are admitted to GenP?

Ulf Engqvist, PhD
Per-Anders Rydelius, Professor, MD, PhD, project leader

Infant Developmental Problems - a Treatment Study

Mothers of infants seek help with their own well-being, symptoms in the baby, and their contact with the child. An immediate and urgent intervention might, it is hypothesized, also prevent later psychopathological development in child and mother. If psychotherapy is offered, its quality should be assured.

Eighty mother-infant dyads with children under 18 months were interviewed. There are few outcome studies. If we could develop evidence-based treatments for this young population, and if their preventive potentials could be substantiated, the significance of the project should be obvious: to decrease present psychic distress and to diminish the risk of further negative development.

The project aims at increasing our knowledge of how intensive psychotherapy and normal health care interventions affect infant and maternal distress, and which psychoanalytic theoretical models best describe different infant problems and how the problems fare in treatment.


  • Which treatment is most effective on maternal well-being and child development: mother-infant psychoanalysis or ordinary care at the Well Baby Clinic?
  • For which dyads is either treatment most indicated?
  • How do mothers describe their infants' developmental problems?


Semi-structured and video-taped interviews are conducted with mother-baby dyads. The dyads are then randomized to psychoanalysis or treatment as usual at Well Baby Clinics. Psychoanalyses are administered by the Infant Service at the Swedish Psychoanalytical Society in Stockholm. The nature of treatment as usual will be explored in each case. After 1,5 year, interviews #2 assess short-term treatment results. At 4 years of age, interviews #3 assess development on a longer basis.

Björn Salomonsson, MD
Per-Anders Rydelius, Professor, MD, PhD, project leader


Contact: Per-Anders Rydelius, project leader