The IMPROVE study

The Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population study (IMPROVE) study.

The IMPROVE study is a longitudinal cohort study performed in 7 centers in 5 European countries (Finland, France, Italy, the Netherlands, and Sweden). Three thousand four hundred eighty-two subjects (median age 64.1 years; 47.8% men) with ≥ 3 vascular risk factors were recruited and monitored for carotis intima media thickness (IMT), a measure of subclinical atherosclerosis. Baseline measurements of IMT were performed between March 2004 and April 2005. Subjects were also asked to fill in a questionnaire. Repeated IMT measurements were performed after 15 months and 30 months, respectively. The study enrolled in total 3711 individuals, aged 54-79 years, who had no cardio- or cerebro-vascular diagnosis before enrolment. Of these 540 Swedish subjects were recruited from the Cohort of 60-year-olds. A wide range of exposures, including genetic markers and other biological markers analysed in blood samples, are studied with the purpose to assess their association with IMT measurements and risk of future cardiovascular events.

  Financing

  • Swedish Research Council
  • Heart & Lung Foundation
  • Stockholm County Council (ALF)
  • the Cardiovascular Programme at Karolinska Institutet
  • European Union grant

Contact persons

Professor, senior

Ulf De Faire

Organizational unit: Cardiovascular epidemiology
E-mail: Ulf.deFaire@ki.se

Assistant professor

Karin Leander

Phone: +46-(0)8-524 874 98
Organizational unit: Cardiovascular epidemiology
E-mail: Karin.Leander@ki.se

Senior lecturer, Chief physician

Bruna Gigante

Phone: +46-(0)8-524 870 82
Organizational unit: Cardiovascular epidemiology
E-mail: Bruna.Gigante@ki.se