Project: Anticancer effects of statins; Akt signaling pathways
Statins have been shown to have anticancer effects and to sensitize tumor cells to cytostatic drugs. Our data show that statins regulate nuclear Akt activity via P2X7 receptors. An involvement of P2X7 might explain many of the pleiotropic and anti-carcinogenic effects of statins and the role of these receptors in the regulation of Akt/PTEN tumor suppressor pathway is studied.
Ulla Stenius, Professor