Lena Palmberg Research group

Senior researcher

Lena Palmberg

Phone: +46-(0)8-524 822 10
Organizational unit: Lungtoxicology
E-mail: Lena.Palmberg@ki.se

Projects

Inflammatory mechanisms in chronic bronchitis – studies in vivo and in vitro

Chronic bronchitis is a disease which is characterized by chronic productive cough that often occurs in smokers and as a consequence of occupational exposures, such as farming. Chronic bronchitis is a separate disease entity but co-varies with chronic obstructive pulmonary disease (COPD). As chronic bronchitis increases the risk of development of COPD and is associated with a poor prognosis when occurring in patients with COPD it is of utmost importance to explore the patho-physiological mechanisms behind the condition in patients. By using advanced 3D-models with human primary bronchial epithelial cells of both a normal and a chronic bronchitis-like mucosa and combine those with immune effector cells, these mechanisms can be evaluated in more details and different treatment strategies can be evaluated.

Financing

  • The Swedish Heart-Lung Foundation
  • The Swedish Research Council
  • Swedish Fund for Research without Animal Experiments

Senior researcher

Lena Palmberg

Phone: +46-(0)8-524 822 10
Organizational unit: Lungtoxicology
E-mail: Lena.Palmberg@ki.se

New systems for exposing human 3D-models of airway mucosa in health and disease to particulate- and gaseous air pollutants

Exposure to agents via inhalation is of great concerns both in workplace environment and in the daily contact with particles in the ambient air. Reliable human airway exposure systems will most likely replace animal experiment in future toxicity assessment studies of inhaled agents.

Financing

  • The Swedish Heart-Lung Foundation
  • The Swedish Research Council
  • Swedish Fund for Research without Animal Experiments
  • IMM’s strategic grants 2016 for pilot collaboration projects

Senior researcher

Lena Palmberg

Phone: +46-(0)8-524 822 10
Organizational unit: Lungtoxicology
E-mail: Lena.Palmberg@ki.se

Detailed study on Toll-like receptor (TLR) mediated immune and pro-inflammatory response to carbon nanoparticle exposure in vitro

The combination of relevant human bronchial mucosa models and sophisticated exposure system can mimic in vivo conditions and serve as a useful alternative animal testing tool when studying adverse effects of nanoparticles, a research field under intense growth. In this study the role of TLR mediated pro-inflammatory and oxidative signaling pathway after carbon nanoparticle exposure is explored by using TLR pathway PCR array assay.

Financing

  • Long-Term Research Fellowship, European Respiratory Society
  • The Swedish Heart-Lung Foundation
  • The Swedish Research Council
  • Swedish Fund for Research without Animal Experiments

Assistant professor

Swapna Upadhyay

Organizational unit: Lungtoxicology
E-mail: swapna.upadhyay@ki.se