Health effects of air pollution

Projects at the Unit of Environmental Epidemiology, Institute of Environmental Medicine (IMM)

Traffic-related air pollution in relation to respiratory and other health effects from infancy to adulthood

The main objective of the project is to study adverse health effects in children, adolescents and young adults related to exposure to air pollution from traffic. A particular aim is to try to disentangle effects of exposure to exhaust emissions, such as ultrafine particles, from those related to coarse particles resulting from road and tire wear. Health effects of interest include wheezing, asthma, allergic sensitization, disturbances of lung function and psychiatric disorders. It is based on several birth cohorts, including BAMSE, EMIL and Born-into-Life. A special feature of the study is the longitudinal prospective follow-up of the study subjects from birth with repeated questionnaires and clinical tests, including blood samples and lung function measurements. Furthermore, a methodology has been developed for detailed individual assessment of exposure to various air pollution components based on longitudinal information regarding addresses of homes, day care centers and schools as well as on emission data bases and dispersion modeling. The combination of longitudinal information on exposure and various health outcomes from birth until adulthood and detailed air pollution exposure assessment based on residential as well as other relevant addresses makes this project unique in the world.

Financing

  • Swedish Research Council
  • Swedish Research Council FORMAS

Contact person

Professor/senior physician

Göran Pershagen

Phone: +46-(0)8-524 874 60
Organizational unit: Environmental epidemiology
E-mail: Goran.Pershagen@ki.se

Associate professor

Erik Melén

Phone: +46-(0)8-524 875 08
Organizational unit: Environmental epidemiology
E-mail: Erik.Melen@ki.se

Publications

Elemental composition of particulate matter and the association with lung function.
Eeftens M, Hoek G, Gruzieva O, Mölter A, Agius R, Beelen R, et al
Epidemiology 2014 Sep;25(5):648-57

Associations between particulate matter elements and early-life pneumonia in seven birth cohorts: results from the ESCAPE and TRANSPHORM projects.
Fuertes E, MacIntyre E, Agius R, Beelen R, Brunekreef B, Bucci S, et al
Int J Hyg Environ Health 2014 Nov;217(8):819-29

Exposure to air pollution from traffic and neurodevelopmental disorders in Swedish twins.
Gong T, Almqvist C, Bölte S, Lichtenstein P, Anckarsäter H, Lind T, et al
Twin Res Hum Genet 2014 Dec;17(6):553-62

Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts.
Gruzieva O, Gehring U, Aalberse R, Agius R, Beelen R, Behrendt H, et al
J. Allergy Clin. Immunol. 2014 Mar;133(3):767-76.e7

Air pollution during pregnancy and childhood cognitive and psychomotor development: six European birth cohorts.
Guxens M, Garcia-Esteban R, Giorgis-Allemand L, Forns J, Badaloni C, Ballester F, et al
Epidemiology 2014 Sep;25(5):636-47

Air pollution and respiratory infections during early childhood: an analysis of 10 European birth cohorts within the ESCAPE Project.
MacIntyre E, Gehring U, Mölter A, Fuertes E, Klümper C, Krämer U, et al
Environ. Health Perspect. 2014 Jan;122(1):107-13

Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study.
Gehring U, Wijga A, Hoek G, Bellander T, Berdel D, Brüske I, et al
Lancet Respir Med 2015 Dec;3(12):933-42

Exposure to grass pollen--but not birch pollen--affects lung function in Swedish children.
Gruzieva O, Pershagen G, Wickman M, Melén E, Hallberg J, Bellander T, et al
Allergy 2015 Sep;70(9):1181-3

A multicentre study of air pollution exposure and childhood asthma prevalence: the ESCAPE project.
Mölter A, Simpson A, Berdel D, Brunekreef B, Custovic A, Cyrys J, et al
Eur. Respir. J. 2015 Mar;45(3):610-24

Perinatal Exposure to Traffic-Related Air Pollution and Autism Spectrum Disorders.
Gong T, Dalman C, Wicks S, Dal H, Magnusson C, Lundholm C, et al
Environ. Health Perspect. 2017 Jan;125(1):119-126

Air Pollution Exposure during Pregnancy and Childhood Autistic Traits in Four European Population-Based Cohort Studies: The ESCAPE Project.
Guxens M, Ghassabian A, Gong T, Garcia-Esteban R, Porta D, Giorgis-Allemand L, et al
Environ. Health Perspect. 2016 Jan;124(1):133-40

Early-Life Exposure to Traffic-related Air Pollution and Lung Function in Adolescence.
Schultz E, Hallberg J, Bellander T, Bergström A, Bottai M, Chiesa F, et al
Am. J. Respir. Crit. Care Med. 2016 Jan;193(2):171-7

Early life exposure to traffic-related air pollution and lung function in adolescence assessed with impulse oscillometry.
Schultz E, Hallberg J, Gustafsson P, Bottai M, Bellander T, Bergström A, et al
J. Allergy Clin. Immunol. 2016 Sep;138(3):930-932.e5


Health effects of air pollution from different sources in relation to cardiovascular and metabolic diseases as well as cancer

Large parts of the population are exposed to increased levels of ambient air pollution, particularly in urban areas. Long-term exposure to air pollution can cause severe health effects, such as respiratory, cardiovascular and/or metabolic diseases. In this project we will significantly strengthen the basis for the risk assessment using data from a number of adult cohorts based in Stockholm county. Individual long-term exposure to air pollutants from different sources is estimated for the cohort members using models with high spatial resolution. Exposure-response relationships will then be assessed for several adverse health outcomes, including hypertension, ischemic heart disease, stroke, various types of cancer, overweight and type 2 diabetes. This will be combined with detailed data on population exposures to calculate the number of cases attributable to air pollution exposure. The role of gender and socioeconomic status is also assessed. It is expected that the results will provide important guidance for prioritization of preventive measures as well as for health sustainable urban development.

Financing

  • European Union
  • Swedish Environmental Protection Agency
  • US Health Effects Institute

Contact persons

Professor/senior physician

Göran Pershagen

Phone: +46-(0)8-524 874 60
Organizational unit: Environmental epidemiology
E-mail: Goran.Pershagen@ki.se

Adjunct professor

Tom Bellander

Phone: +46-(0)8-524 800 03
Organizational unit: Environmental epidemiology
E-mail: Tom.Bellander@ki.se

Associated

Petter Ljungman

Organizational unit: Environmental epidemiology
E-mail: Petter.Ljungman@ki.se

Publications

Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE).
Raaschou-Nielsen O, Andersen Z, Beelen R, Samoli E, Stafoggia M, Weinmayr G, et al
Lancet Oncol. 2013 Aug;14(9):813-22

Long term exposure to ambient air pollution and incidence of acute coronary events: prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project.
Cesaroni G, Forastiere F, Stafoggia M, Andersen Z, Badaloni C, Beelen R, et al
BMJ 2014 Jan;348():f7412

Comparing land use regression and dispersion modelling to assess residential exposure to ambient air pollution for epidemiological studies.
de Hoogh K, Korek M, Vienneau D, Keuken M, Kukkonen J, Nieuwenhuijsen M, et al
Environ Int 2014 Dec;73():382-92

Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE).
Fuks K, Weinmayr G, Foraster M, Dratva J, Hampel R, Houthuijs D, et al
Environ. Health Perspect. 2014 Sep;122(9):896-905

Mortality related to air pollution with the moscow heat wave and wildfire of 2010.
Shaposhnikov D, Revich B, Bellander T, Bedada G, Bottai M, Kharkova T, et al
Epidemiology 2014 May;25(3):359-64

Long-term exposure to ambient air pollution and incidence of cerebrovascular events: results from 11 European cohorts within the ESCAPE project.
Stafoggia M, Cesaroni G, Peters A, Andersen Z, Badaloni C, Beelen R, et al
Environ. Health Perspect. 2014 Sep;122(9):919-25

Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: results from the ESCAPE and TRANSPHORM projects.
Wang M, Beelen R, Stafoggia M, Raaschou-Nielsen O, Andersen Z, Hoffmann B, et al
Environ Int 2014 May;66():97-106

Natural-cause mortality and long-term exposure to particle components: an analysis of 19 European cohorts within the multi-center ESCAPE project.
Beelen R, Hoek G, Raaschou-Nielsen O, Stafoggia M, Andersen Z, Weinmayr G, et al
Environ. Health Perspect. 2015 Jun;123(6):525-33

Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts.
Hampel R, Peters A, Beelen R, Brunekreef B, Cyrys J, de Faire U, et al
Environ Int 2015 Sep;82():76-84

Traffic-related air pollution exposure and incidence of stroke in four cohorts from Stockholm.
Korek M, Bellander T, Lind T, Bottai M, Eneroth K, Caracciolo B, et al
J Expo Sci Environ Epidemiol ;25(5):517-23

Air Pollution from Road Traffic and Systemic Inflammation in Adults: A Cross-Sectional Analysis in the European ESCAPE Project.
Lanki T, Hampel R, Tiittanen P, Andrich S, Beelen R, Brunekreef B, et al
Environ. Health Perspect. 2015 Aug;123(8):785-91

Air pollution and atherosclerosis: a cross-sectional analysis of four European cohort studies in the ESCAPE study.
Perez L, Wolf K, Hennig F, Penell J, Basagaña X, Foraster M, et al
Environ. Health Perspect. 2015 Jun;123(6):597-605

Long-term impact of moscow heat wave and wildfires on mortality.
Shaposhnikov D, Revich B, Bellander T, Bedada G, Bottai M, Kharkova T, et al
Epidemiology 2015 Mar;26(2):e21-2

Spatial variation of PM elemental composition between and within 20 European study areas--Results of the ESCAPE project.
Tsai M, Hoek G, Eeftens M, de Hoogh K, Beelen R, Beregszászi T, et al
Environ Int 2015 Nov;84():181-92

Long-term Exposure to Particulate Matter Constituents and the Incidence of Coronary Events in 11 European Cohorts.
Wolf K, Stafoggia M, Cesaroni G, Andersen Z, Beelen R, Galassi C, et al
Epidemiology 2015 Jul;26(4):565-74

Can dispersion modeling of air pollution be improved by land-use regression? An example from Stockholm, Sweden.
Korek M, Johansson C, Svensson N, Lind T, Beelen R, Hoek G, et al
J Expo Sci Environ Epidemiol 2016 Aug;():

Elemental Constituents of Particulate Matter and Newborn's Size in Eight European Cohorts.
Pedersen M, Gehring U, Beelen R, Wang M, Giorgis-Allemand L, Andersen A, et al
Environ. Health Perspect. 2016 Jan;124(1):141-50

Particulate matter air pollution components and risk for lung cancer.
Raaschou-Nielsen O, Beelen R, Wang M, Hoek G, Andersen Z, Hoffmann B, et al
Environ Int 2016 Feb;87():66-73


DANTE Device detected atrial fibrillation and environmental exposures

We investigate how short-term and long-term air pollution may trigger or increase the burden of paroxysmal atrial fibrillation in patient with pacemaker devices.

Financing

  • The Swedish Research Council for Health Working Life and Welfare

Contact person

Associated

Petter Ljungman

Organizational unit: Environmental epidemiology
E-mail: Petter.Ljungman@ki.se


Airrest II Air polllution and cardiac arrest

We are investigating how short-term exposure to air pollution may trigger cardiac arrest using an ongoing cardiac arrest registry in Sweden. The potential effect modification by previous hospitalization will also be examined.

Financing

  • The Swedish Research Council for Health Working Life and Welfare

Contact person

Associated

Petter Ljungman

Organizational unit: Environmental epidemiology
E-mail: Petter.Ljungman@ki.se

Graduate Student

Auriba Raza

E-mail: auriba.raza@ki.se


AIRFIB Air pollution and atrial fibrillation

Using a large-scale screening study for paroxysmal atrial fibrillation in 75 year olds in Stockholm, we are investigating associations between short-term air pollution exposure and onset of atrial fibrillation.

Financing

  • Swedish Society for Medical Research

Contact persons 

Associated

Petter Ljungman

Organizational unit: Environmental epidemiology
E-mail: Petter.Ljungman@ki.se

Graduate Student

Marcus Dahlquist

E-mail: marcus.dahlquist@ki.se