Lectures and seminars

IMM Seminar - The Case-Cohort design: What it is and how it can be used in register-based research

2016-01-2814:00 to 15:00 Blå hallen, IMM, Nobels väg 13Campus Solna


Anna Johansson, Statistician, MEB


I will give a brief theoretical background and history of case-cohort studies, which dates back to the key publication by Prentice in 1986. I will talk about in which situations the case-cohort design is useful, in particular in a register-based setting with total population registers. I will briefly describe what you can estimate from a case-cohort design and the different weighting schemes to be used in the analysis to account for the sampling. As an example, I will present my own study on risk for breast cancer following pregnancy using data from the Multi-Generation Register and the Swedish Cancer Register. In this study we utilised the case-cohort design to reduce the dataset and to improve computational efficiency. Some Stata code for how to do it will also be presented.


Josefin Edwall Löfvenborg, MSc Nutrition, PhD student, Unit of Epidemiology, IMM

Contact person: Josefin Edwall Löfvenborg