Tumor cells display metabolic profiles that are remarkably distinct from their tissue of origin to ensure fulfillment of their higher bioenergetic/biosynthetic needs to support a rapid proliferation. The mechanisms underlying this metabolic reprogramming are divergent among tumors and are often regulated by oncogenes/tumor suppressors.
Associate Professor Erik Norberg, Ph.D
Mathilda Eriksson, Ph.D
Boxi Zhang, Ph.D
André Lima Queiroz, Ph.D
Yiwei Ai, MD, Karolinska Institutet
Wirood Aldjezani, MSc, Uppsala University
Dawn E. Comstock, MD-Ph.D, Harvard Medical School
Dominique Smith, MSc, Uppsala University
We are mainly focusing on the following overarching topics:
- Metabolic Adaptations to Oncogenes and Tumor Suppressors
- Metabolic Signal Transduction
- Pharmacological Approaches to Target Metabolic Circuits
- Metabolic Control of Epigenetics
- Regulation and maintenance of metabolic heterogenety
To study these questions we employ a translational approach starting from primary patient material paralleled by studies to elucidate the molecular mechanisms in cancer cells, normal cells and cancer mouse models, with the ultimate goal of identifying novel drug targets and prognostic markers.
We are assessing the above mentioned aims by an integrative approach consisting of metabolomics, proteomics and transcriptomics as well as various genetic, biochemical and molecular biological tools.
We are collaborating with colleagues at Harvard Medical School (Boston, MA, USA), several groups at Karolinska Institutet and The Royal Institute of Technology.
PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis.
Cell Rep 2017 Jun;19(11):2289-2303
Characterization of the Role of the Malate Dehydrogenases to Lung Tumor Cell Survival.
Zhang B, Tornmalm J, Widengren J, Vakifahmetoglu-Norberg H, Norberg E. J Cancer 2017; 8(11):2088-2096.
Differential contribution of the mitochondrial translation pathway to the survival of diffuse large B-cell lymphoma subsets.
Cell Death Differ. 2017 Feb;24(2):251-262
The role of mitochondria in metabolism and cell death.
Biochem. Biophys. Res. Commun. 2017 Jan;482(3):426-431
Glucose metabolism provide distinct prosurvival benefits to non-small cell lung carcinomas.
Biochem. Biophys. Res. Commun. 2015 May;460(3):572-7
Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.
J. Cell Biol. 2015 Aug;210(5):705-16
Changing appetites: the adaptive advantages of fuel choice.
Trends Cell Biol. 2014 Feb;24(2):118-27
Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma.
Cancer Cell 2012 Oct;22(4):547-60
Erik Norberg co-first author: