Biomimetic constructs for tissue-engineering applications

The objective of the research project is to develop and evaluate novel biomimetic devices for reconstructing periodontal and craniofacial bone defects based on the detailed biological investigation of the adult mesenchymal progenitor cells (MSCs), and the extracellular matrix (ECM) produced in vitro.

With that goal, different biomaterials, alone or in combination with MSCs, are tested in vitro and in vivo. The project will increase understanding of the action, and the optimization of the ECM-based tissue-engineered constructs that may become a very effective clinical application.

During the past years the research has been mainly supported by the Karolinska Institutet, and the Stockholm County Council. In 2012 Dr. Ion Tcacencu has received funding from the European Union's Seventh Framework Programme under grant agreement No. 280575 for the project entitled "Resorbable Ceramic Biocomposites for Orthopaedic and Maxillofacial Applications" (RESTORATION) where he is responsible for the Work-package N.6 “Biological Enhancement and Assessment” ( ). The allocated EU contribution is around 385000 EURO. The duration of the project is 48 month and involves 11 research partners from EU.

Principal Investigator

  • Ion Tcacencu