Peter Nordström/Jussi Jokinen´s research group

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Risk assessment, management and prevention in clinical psychiatry

Suicide and violence are important public health problems. Clinical suicide prevention needs a more detailed knowledge of neurobiological correlates to personality traits and behaviour in attempted suicide and violent offending for treatment implications and prevention. We are investigating risk factors for both suicidal and violent behavior.

We published in 2010 a new clinical rating scale: The Karolinska Interpersonal Violence Scale (KIVS) which can be used in suicide risk assessment after attempted suicide. Suicide attempters who committed suicide during the follow-up had significantly higher scores in exposure to violence as a child and in expressed violent behaviour as an adult compared to survivors.

We are studying neuroendocrine and neuroinflammatory markers in suicide attempters in relation to different outcomes and to assess whether interpersonal violence or personality traits can be associated to specific biomarkers. Several studies concern interrelationship between violence and suicide in different cohorts. A research project investigates psychiatric comorbidity in Multiple sclerosis (MS) in relation to neuroinflammatory markers and pharmacological treatment. We also study effect of DBT based psychoeducational program for family members of suicide attempters as a complementary treatment option.

Research Projects

  • Hypothalamic-pituitary-thyroid (HPT) axis in attempted suicide
  • Risk Factors for Violence; Clinical, Biological and Epidemiological Studies
  • Clinical Rating Scales in Suicide Prediction
  • Cholesterol and serotonin in suicidal behaviour
  • Neuroinflammatory biomarkers in suicidal behaviour
  • Neuroendocrine studies in suicide attempters and in hypersexual disorder
  • Psychiatric comorbidity in multiple sclerosis; biological and epidemiological aspects
  • Suicide attempters and their significant others

Selected Publications

High interleukin-6 and impulsivity: determining the role of endophenotypes in attempted suicide.
Isung J, Aeinehband S, Mobarrez F, Nordström P, Runeson B, Asberg M, et al
Transl Psychiatry 2014 Oct;4():e470

CSF 5-HIAA, cortisol and DHEAS levels in suicide attempters.
Chatzittofis A, Nordström P, Hellström C, Arver S, Åsberg M, Jokinen J
Eur Neuropsychopharmacol 2013 Oct;23(10):1280-7

Low CSF oxytocin reflects high intent in suicide attempters.
Jokinen J, Chatzittofis A, Hellström C, Nordström P, Uvnäs-Moberg K, Asberg M
Psychoneuroendocrinology 2012 Apr;37(4):482-90

Karolinska Interpersonal Violence Scale predicts suicide in suicide attempters.
Jokinen J, Forslund K, Ahnemark E, Gustavsson J, Nordström P, Asberg M
J Clin Psychiatry 2010 Aug;71(8):1025-32

Association of suicide attempts with acne and treatment with isotretinoin: retrospective Swedish cohort study.
Sundström A, Alfredsson L, Sjölin-Forsberg G, Gerdén B, Bergman U, Jokinen J
BMJ 2010 Nov;341():c5812

Group Members

Andreas ChatzittofisAssociated
Anna-Lena NordströmAssociated
Cave SinaiAssociated
Josef IsungAssociated
Jussi JokinenAssociated
Jón Hallur StefánssonGraduate Student
Marlene StenbackaAssociated
Peter NordströmAssociated, Research team leader
Philip BrennerGraduate Student
Pär SvanborgAssociated
Tomas MobergAssociated