Nils Lindefors research group

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Psychiatric Diagnosis and Treatment

Clinical psychiatry offers a number of effective treatments, but it is still too common that patients in the end not quite achieve normalization (remission). Furthermore, the organizational aspects of psychiatric care are still immature with respect to effectiveness and service. We need to continue to develop treatment selection and efficiency and developing care processes, in order to increase accessibility to good health care and for increased value for patients (e.g. quality of life, good health and autonomy).

Nils Lindefors research line focus on psychiatric treatment and health economy. Primary objective is to develop safe and cost-effective procedures for diagnosis, treatment and monitoring of outcome.

The research group follows two main lines of research. The first concerns the methodology, applicability and effectiveness of Internet-mediated cognitive-behavioral therapy (ICBT); how the effect is affected by factors such as disease expression (symptoms), personality and genes. Results are measured both in terms of value for patients and society, i.e. that we look both to that which benefits the patient and measure the health economic consequences. So far we have evaluated and made available ICBT for depression, panic disorder, social anxiety disorder and irritable bowel syndrome (IBS) and we currently are working with continuous improvements and new applications.

The second line of research is clinical drug trials. In an ongoing researcher initiated and drug industry independent study we examine how methylphenidate may be used in the treatment of ADHD for prison inmates.

Research Projects

  • Insomni och depression: randomiserad prövning av internetbaserad kombinationsbehandling för patienter med båda diagnoserna
  • Effectiveness and health economy of internet delivered cognitive behavior therapy (ICBT) for Irritable Bowel Syndrome (IBS)
  • Effectiveness and health economy of internet delivered cognitive behavior therapy (ICBT) for health anxiety
  • Effectiveness of methylphenidate in Swedish male prison inmates with atten-tion-deficit hy-peractivity disorder (ADHD)
  • Multimodal treatment of attention-deficit hyperactivity disorder (ADHD)

Selected publications

Internet administration of self-report measures commonly used in research on social anxiety disorder: A psychometric evaluation 
Hedman E, Ljótsson B, Rück C, Furmark T, Carlbring P, Lindefors N, Andersson G 
Computers in Human Behavior 2010 Jul; 26(4):736-740

Attention Deficit Hyperactivity Disorder (ADHD) among longer-term prison inmates is a prevalent, persistent and disabling disorder.
Ginsberg Y, Hirvikoski T, Lindefors N
BMC Psychiatry 2010 Dec;10():112

Changes in dopamine D2-receptor binding are associated to symptom reduction after psychotherapy in social anxiety disorder.
Cervenka S, Hedman E, Ikoma Y, Djurfeldt D, Rück C, Halldin C, et al
Transl Psychiatry 2012 May;2():e120

Effectiveness of internet-based cognitive behaviour therapy for panic disorder in routine psychiatric care.
Hedman E, Ljótsson B, Rück C, Bergström J, Andersson G, Kaldo V, et al
Acta Psychiatr Scand 2013 Dec;128(6):457-67

Effectiveness of Internet-based cognitive behaviour therapy for depression in routine psychiatric care 
Hedman E, Ljótsson B, Kaldo V, Hesser H, El Alaoui S, Kraepelien M, Andersson E, et al. 
Journal of Affective Disorders 2014 Feb;155:49-58

Group members


Cecilia SvanborgAssociated
Johan SöderlundAssociated
Lina MartinssonAssociated
Nils LindeforsAssociated, Research team leader, Adjunct professor
Samir El AlaouiAssociated
Sara PankowskiGraduate Student