Research Areas

CMB is comprised of more than 30 independent research groups organized in three themes: Cell Biology, Developmental and Stem Cell Biology and Infection and Cancer.

Cell Biology

The central aim of the research within the Cell Biology theme is to gain a deeper understanding of the biology of the eukaryotic cell.

Through detailed characterization of fundamental molecular mechanisms of normal and perturbed cells, the theme strives to unravel information that increases the understanding of various diseases such as cancer and neurodegenerative, cardiovascular and inflammatory disorders.

The key interests lie within the field of genome integrity and variation, cell division, regulation of gene expression, protein turnover and signal transduction. These areas are approached by investigations that span from structural characterization of single molecules, macromolecular interactions and supramolecular assemblies, over mapping of molecular pathways in different model organisms, to whole genome sequencing of human pathogens. Thus the theme encloses expertise within bioinformatics, biophysics, biochemistry, molecular cell biology and genetics. This and its interactive atmosphere allow the theme to form a creative network for cutting edge research.

Research groups

Name, link to profile Link to research group and project
Björn Andersson Genomic analysis of parasites and viruses, metagenomic sequencing
Bertil Daneholt The passage of the mRNP particle through the nuclear pore
Nico Dantuma Ubiquitin/proteasome system, development of neurodegenerative diseases and cancer
Martin Hällberg Structural basis of RNA biogenesis
Christer Höög Meiotic chromosome segregation
Randall Johnson Effects of hypoxia in physiological and pathological contexts, Hypoxia Inducible Factors (HIF)
Andreas Kegel The topological function of the evolutionarily conserved Smc5/6 complex
Arne Lindqvist Cell cycle, mitotic entry, and DNA-damage checkpoints
Lars Norlén Basic molecular structure of human skin
Olle Sangfelt SCF ubiquitin ligases, cell cycle, transcription and cancer development
Camilla Sjögren The SMC complexes, chromosome dynamics and stability
Lena Ström Sister chromatid cohesion in DNA damage responses, DSB repair, Genome Integrity, Gene regulation
Björn Vennström Thyroid hormone, developmental and metabolic processes
Örjan Wrange Chromatin, epigenetics and gene regulation, steroid receptors


Developmental and Stem Cell Biology


The stem cell and developmental biology program at CMB is engaged in a broad range of basic research aimed at understanding the molecular mechanisms underlying diverse aspects of embryonic development and tissue regeneration.

The long-term vision is that the delineation of key developmental strategies, and identification of molecules involved in these processes, will provide new paradigms in cellular transplantation and regenerative medicine.

Key areas of investigation are the identification and functional characterization of stem cell niches in developing tissues and adult organs. This research aims at characterizing molecules and signals involved in controlling the undifferentiated state and self-renewal capacity of stem cells, and to develop methods to direct the differentiation of stem cells into clinically relevant cell types. Extensive emphasis is also made on tissue differentiation and growth during embryogenesis, and deciphering mechanisms underlying the establishment cellular diversity in developing tissues and organs. Many of these questions are addressed in studies of the developing nervous system and in the mature brain.

A wide range of technical platforms and model organisms are applied to pursue relevant research topics. Basic genetic and molecular biology methodologies are combined with complementary bioinformatic and genome-wide approaches, allowing investigation global molecular changes in cells in various differentiation processes.

Research groups

Name, link to profile Link to research group and project
Emma Andersson Genetic basis of complex diseases
Olov Andersson Drug discovery, pancreatic beta-cell regeneration
Kenneth Chien Stem cells, Developmental Biology, Heart Disease, Heart Development, Genetics, Biotechnology
Qiaolin Deng Gene regulation in early fate specification after implantation
Johan Ericson Stem cells and neural development
Jonas Frisén Stem Cells in Tissue Homeostasis and Regenerative Medicine
Maria Genander Epithelial stem cells in development and disease
Christian Göritz Homeostasis and tissue repair mechanisms in the mammalian system, pericytes, stem cells
Johan Holmberg Cellular diversity is generated during development, neuronal identity
Sten Eirik Jacobsen Hematopoietic stem cells in normal and malignant development and regenerative medicine
Urban Lendahl Notch signaling, ES cells, myogenic and vascular progenitors, vascular disease and Alagille syndrome, breast cancer
Jonas Muhr Stem Cell Biology
Thomas Perlmann Development, transcription factors, neurons, dopamine
Rickard Sandberg Gene regulation, genome-wide experimental and computational techniques
Andras Simon Regeneration mechanisms
Kirsty Spalding Tissue regeneration, focusing on fat cells (adipocytes) and obesity

Infection and Cancer

The aim of the Infection and Cancer theme is to study how latent viral infections and chronic bacterial infections are associated with the development of cancer.

Common infectious diseases remain a major cause of morbidity and mortality worldwide. This is illustrated by the emergence of antibiotic resistant bacteria, and highly pathogenic viruses, such as HIV, SARS and new strains of influenza. In addition, infections contribute or are suspected to contribute to a surprisingly broad spectrum of malignancies.

We are focusing on the pathogen-host interaction at the cellular, tissue and organism levels, and are interested in understanding how this interaction alters processes involved in the regulation of genomic stability, cell cycle progression, cell death, and cellular and tissue re-modelling. The models used in our research are: the lymphotropic Epstein-Barr virus (EBV) and bacteria producing the cytolethal distending toxin (CDT), a bacterial genotoxin.

EBV is a DNA tumor virus that establishes latent infections in 90% of the human population world-wide. EBV has a dual life cycle characterized by the establishment of latency in B-lymphocytes and productive infection in epithelial cells. Latently infected B-cells express a restricted set of viral genes that promote a global rearrangement of the cellular environment leading to B-cell growth transformation and immortalization. The capacity of the latency viral gene to reprogram the control of cell proliferation and apoptosis and deregulate the maintenance of genome integrity is likely to underlie the association of EBV with a variety of malignancies, including virtually all cases of endemic Burkitt's lymphoma (BL) and nasopharyngeal carcinoma (NPC) and approximately half of Hodgkin's lymphomas (HL). Understanding the longstanding question of EBV oncogenesis in immuno-competent individuals is a crucial question.

Many pathogenic bacteria are highly pro-inflammatory and certain bacterial infections have been associated with increase cancer risk (e.g. Helicobacter pylori and gastric cancer). However, the exact mechanisms by which chronic bacterial infections contribute to carcinogenesis are poorly understood. Constitutive expression of TNF- alpha and activation of the transcription factor NF-kB seems to play a key role in the transition from chronic infection to malignancy. Several Gram-negative bacteria produce potentially DNA- damaging factors, including toxins, such as CDT, that may cause genetic instability and promote malignant transformation. In addition, some bacterial pattern molecules and virulence factors affect apoptosis and the control of cell cycle. Inflammation, induction of genetic instability, interference with cell cycle regulation and apoptosis could contribute to generate a carcinogenic tissue environment.

The groups in the Infection and Cancer theme focus on the following specific topics:

  1. Viral and bacterial induced deregulation of cell cycle control
  2. Viral and bacterial induced genomic instability
  3. Interaction of infected cells with the surrounding micro-environment
  4. Viral and bacterial interference with the ubiquitin proteasome system
  5. Meta-genomic screening for identification of new viruses

Research groups

Name, link to profile Link to research group and project
Björn Andersson Genomic analysis of parasites and viruses, metagenomic sequencing
Teresa Frisan Carcinogenic properties of chronic infection with CDT-producing bacteria, toxin internalization, induction of genomic instability, tissue remodelling
Maria G. Masucci Molecular Mechanisms of Viral Oncogenesis