Growth Factor Receptor Signaling and Biology in Nervous System Development and Metabolic Regulation
With a focus on growth factor receptor signaling, we investigate different aspects of nervous system development and metabolic regulation. Currently, our studies center on three different ligand/receptor systems:
- p75 neurotrophin receptor and neurotrophin family ligands
- GFRα1, Ret and NCAM receptors and GDNF family ligands
- TGF-β superfamily receptors ALK7 and ALK4 and their ligands Activins and GDFs.
Using these signaling systems as entry points, our goal is to discover novel, general biological principles of broad importance for nervous system development and metabolic functions.
Current topics of investigation
- Mechanism of p75NTR death receptor activation and downstream signal propagagation
- Role of GDNF family signaling in nervous system development
- Mechanisms underlying the development and differentiation of cortical GABAergic interneurons
- Activin receptor signaling in pancreatic beta-cell function and adipose tissue homeostasis
- A chemical-genetic approach to study activin receptor signaling in metabolic regulation
Critical role of GFRα1 in the development and function of the main olfactory system.
J. Neurosci. 2012 Nov;32(48):17306-20
Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor.
Cell Rep 2012 Dec;2(6):1563-70
Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity.
Elife 2014 Aug;3():e03245
Topographical transcriptome mapping of the mouse medial ganglionic eminence by spatially resolved RNA-seq.
Genome Biol. 2014 ;15(10):486
Structural basis of death domain signaling in the p75 neurotrophin receptor.
Elife 2015 Dec;4():e11692
Annika Andersson - Research assistant
Shounak Baksi - Postdoc
Diana Fernandez Suarez - Postdoc
Christina Göngrich - Postdoc
Carlos Ibanez - Professor
Claire Elizabeth Kelly - Postdoc
Lilian Kisiswa - Postdoc
Annalena Moliner - Laboratory engineer
Patricia Mármol Carrasco - Postdoc
Favio Krapacher - Postdoc