Researcher - Orthopaedics and Biotechnology

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Berg, Hans


Hans BergMD, Associate Professor
Hans Berg

Has a PhD on human muscle atrophy and weakness following bedrest inactivity or spaceflight (1996), and is the inventor of a strength training apparatus (using gravity-independent flywheels) that has been used in microgravity studies by ESA and NASA. Also, muscular recruitment and force development during strength training and athletics were studied.

Current studies focus muscular weakness, gait disturbance and morphological changes, including muscular fat infiltration, in orthopaedic patients suffering from osteoarthritis (OA) of the lower limbs. Not only pain alleviation but also restored limb function is nowadays requested after joint replacement surgery. We have recently shown profound muscular atrophy and weakness in hipOA patients; persisting the first 2 years after total hip arthroplasty (THA). Hip, thigh and calf muscle atrophy is mapped out using computerized tomographic (CT) cross-sections. Maximum force development about hip and knee joints are measured using a developed dynamometer.

Another project studies the development and use of a small (focal) knee joint implant for small joint lesions Effective treatment methods for small cartilage defects is lacking. Young individuals may develop chronic disability following focal joint damages during sport, in the workplace or traffic accidents. A new implant and instruments has been developed within a Swedish medical technology project and used in pilot study in sheep. Bone ingrowth and cartilage wear is monitored.

Teaching interest
Orthpaedics, muscle physiology.

Research interest
Orthpaedics, muscle physiology.

Felländer-Tsai, Li

Li TsaiProfessor in orthopedics
Li Felländer-Tsai

Li Felländer-Tsai was appointed Professor of Orthopaedics at Karolinska Institutet in 2006. She is the chairman of the Department of Clinical Science, Intervention and Technology and Director of the Center for Advanced Medical Simulation. She is active in orthopedic education, training and research as well as advanced surgical technology. She has developed and implemented a technique for monitoring of synovial tissue metabolism and inflammation with intraoperative and postoperative microdialysis. Other fields of research include virtual reality and surgical simulation. She is President of the Swedish Orthopedic Society and past registrar and chairman of the Swedish ACL Register (Quality registry for cruciate ligament reconstruction). She chaired the process of Accreditation of the Center for Advanced Medical Simulation and Training as an American College of Surgeons Level I Educational Institute and is now director of the Center.

Teaching interests
Orthopedics, advanced medical simulation

Research interests

Recovery after surgery of the musculoskeletal system, metbolism in the synovial membrane after surgery and local effects of pharmacological and physiological modulation, treatment of knee injuries:

The purpose of the research is to combine a series of stress-reducing factors (both pharmacological and local cooling) to achieve rapid recovery after joint surgery. The goal is good pain relief and optimum healing with good joint function, minimizing the adverse trophic effects on the tissue and osteoarthritis.

Disorders in joint metabolism can lead to osteoarthritis. Better treatment strategies for rapid recovery, healing and maintaining joint function requires a coordinated effort with adequate treatment of pain and inflammation. With microdialysis local tissue effects and pain relief can be studied in the knee synovial membran. The effect of local anaesthetics on the proliferative and differentiating capacity of mesenchymal stem cells are studied.

The findings can modernize pain treatment that does not interfere with healing after surgery and risk factors for osteoarthritis can be identified.

In parallel treatment of knee joint injuries is studied from an epidemiological and rehabilitation aspect.

Advanced medical simulation:

The vision is to create a new de-facto standard for training technical and non technical skills (team behaviour) in high stakes healthcare with advanced medical simulators, where ergonomic principles are followed, and thus optimize patient safety. The aim is also to develop valid and reliable training and assessment instruments for technical skills so that individual training programs can be developed in which individual factors such as working memory and ability visuospatiala can be targeted. When valid measures of team behavior and surgical skills are established, these can be translated into evidence-based training and education with both theory and practice. The ultimate goal is advanced state-of-the-art courses for trainers ( "train the trainer" course) with modern principles of both team training and advanced skills training. By training instructors and teachers the next generation of healthcare professionals will improve skills and attitudes in favour of patient safety.

Gerdhem, Paul

Paul GerdhemAssociate professor, Senior Consultant
Paul Gerdhem

Paul Gerdhem became specialist in Orthopaedics 2000. He defended his thesis titled "Risc factors for falls and fractures in elderly women" 2004 and became associate professor 2005.

His clinical work concerns spinal disorders with a special interest in spinal deformities.

Since 2004 he is the principal investigator of a multicenter study concerning scoliosis and genetics. Since 2013 he is the principal investigator of a multicenter study of conservative treatment for scoliosis. He is a member of the steering committees of the national quality registers Swespine and “Frakturregistret”.

The research activity is focused on spinal disorders; genetic and biochemical studies of scoliosis, conservative treatment of scoliosis, and predictor and outcome studies in scoliosis and disc hernia. Part of the research concerns risk factors for osteoporosis and osteoporotic fractures, of which vertebral fractures is one of the most common fracture types. 

Teaching interests

Orthopaedics, osteoporosis, spinal disorders.

Teaching includes supervision of students during theses projects (15-30 credits) and lectures. Paul Gerdhem is the course leader of courses in spinal disorders and basic orthopaedic skills for residents with about 2 courses per year. 

Research interests

Studies on scoliosis

Idiopathic scoliosis is the most common spinal deformity and affects around 3% of children and adolescents. About one tenth gets an aggressive variant leading to a severe deformity of the spine and thorax and is treated by brace or surgery. Untreated severe scoliosis leads to pulmonary dysfunction and pain.

The hereditary component of idiopathic scoliosis is well known, but the pathogenesis of scoliosis is poorly understood and it is difficult to early identify those at risk of severe scoliosis. Our aim is to increase understanding of the genetic background in idiopathic scoliosis and to find prognostic markers for scoliosis progression by genetic studies.

A randomised controlled trial is ongoing to compare the result from night time brace treatment, postural retraining and observation in patients with idiopathic scoliosis.

Studies on disc hernia

In longitudinal studies, including the Swedish spine register, outcome after surgical procedures are studied to identify predictors of treatment and to identify suboptimal treatment methods.

Using data in three Nordic national spine registers we will study indications and patient reported outcome after surgery for lumbar disc herniation. This can provide important bench-marking information, including guidance in optimal indications for surgery, and relevant predictors for successful outcome.

Studies on osteoporosis and osteoporotic fractures

Using observational population based and cross-sectional case control studies, risk factors for osteoporosis and fractures are studied.

Lindgren, Urban

Urban LindgrenProfessor emeritus
Urban Lindgren

Born in 1943, PhD thesis 1974, shortly thereafter board certified in orthopedic surgery.

Previously worked at the Dep. of Biochemistry, University of Wisconsin-Madison with H.F. DeLuca. Board certified in the United States; during a 3 year period Professor and Chairman. 1987 appointed Professor of orthopedic surgery at KI and Department Chairman at Huddinge University Hospital. Previously chairman for the Division of Orthopedic Surgery at KI/CLINTEC.

Research interests
Continued experimental research. Clinical focus reconstructive surgery, especially joint replacement. Current projects: The importance of SIRT-1 in osteoporosis and osteoarthritis  experimental studies; improved surgical technique for total hip replacement; the importance of metal release from orthopedic implants.