Research projects - Orthopaedics and Biotechnology

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A new joint implant for cartilage resurfacing after knee injury or degeneration

Hans Berg, MD, Associate Professor

Effective treatment methods for small (focal) cartilage defects are lacking. Young individuals may develop chronic disability following focal joint lesions during sport, in the workplace or traffic accidents. A new Swedish implant for focal resurfacing has been developed. This project monitors bone ingrowth and cartilage wear in a sheep model.

Advanced medical simulation

Li Felländer-Tsai, Professor in orthopedics

The vision is to form a new standard for training of technical and non-technical skills in advanced medical simulators following the pinciples of human factors for the benefit of patient safety.

Associations of genetics and bone metabolism to scoliosis, osteoporosis, and fractures

Paul Gerdhem, Associate professor, Senior Consultant

The overall aim of this project is to improve diagnosis and treatment for persons suffering from two disorders affecting the skeleton, osteoporosis and scoliosis.
Idiopathic scoliosis, a deformity of the spine is a condition that occurs during growth and is seen in 3% of all children. Most will not require treatment, but a large number require follow-up, including x-rays, to identify the 0.3% of all children with a progressive scoliosis that requires treatment with brace or surgery. The ethiology of idiopathic scoliosis is unknown. Hereditary studies indicate a familial aggregation. Linkage analyses have indicated that several genes may be involved. Low bone mass has been suggested as a possible ethiology for scoliosis. Since low bone mass (osteoporosis), osteoporotic fractures and scoliosis both affect the skeleton and there are indications of common pathophysiologic pathways, this project studies both scoliosis and osteoporosis.

Developmental programming and later health and disease

Mikael Norman, professor

Epidemiological observations have led to a new paradigm stating that the risk of developing common diseases (such as cardiovascular disease,hypertension and type 2 diabetes) in adulthood is influenced not only by genetic and adult life-style factors but also by environmental factors (malnutrition, stress) acting early in life. In the search for mechanisms, studies in young humans may help. Our research priorities are early detection of abnormalities and identification of modifiable factors in the causal chain, involving molecular, clinical and epidemiological studies. The results have implications for the lifestyle and health risks in children and adults born too small and too early, and may open an opportunity for early preventive strategies and therapeutic interventions, not only applicable in Sweden.

Kinematics and loading in the foot and lower extremities

Toni Arndt, associate professor in biomechanics

Empirical studies are performed in the biomechanical laboratory and also at other collaborating institutions with the aim of describing biomechanical function in the foot and lower extremities. Innovative biomechanical methods have been developed for describing dynamics within the Achilles tendon in terms of strain characteristics during defined movements and walking. Relative motion between the intrinsic segments is being studies together with an international network using a unique method with intracortical pins inserted in vivo in the segments of interest. The purpose of the research is to assist in the understanding of podiatric biomechanics to prevent injury mechanisms, optimise clinical treatment and improve training and sports performance.

Muscle morphology and physical performance in response to ortopaedic surgery

Hans Berg, MD, Associate Professor

Patients with degenerative joint disease (osteoarthritis) develop muscular weakness and painful limp. Not only pain alleviation but also restored limb function are nowadays requested after joint replacement surgery. Current studies map muscular weakness, gait disturbance and morphological changes, including muscular fat infiltration, using CT scanning before and after joint replacement.

Optimal treatment of joint injuries

Li Felländer-Tsai, Professor in orthopedics

To optimize treatment of joint injuries in order to avoid osteoarthritis and to establish pain relief and reduction of inflammation based on evidence-grade 1 through active multi-disciplinary collaboration in orthopedics, anestesthesia as well as metabolic- and inflammatort research.