Research and group leaders
BioNut Research Areas
Functional genomics involves making use of the vast amount of data produced by genomic projects such as genome sequencing with the aim of describing gene functions and interactions.
Functional genomics focuses on dynamic aspects such as gene transcription, translation, and protein-protein interactions. Functional genomics includes also function-related aspects of the genome itself such as mutation and polymorphism Functional genomics involves measurements of molecular activities, often using high-throughput technologies.
Functional genomics includes, but is not limited to, measurements of transcript levels (transcriptomics), protein levels (proteomics), metabolite levels (metabolomics), protein interactions and studies in model organisms and many other approaches. Bioinformatics is a critical component of functional genomics.
Research within nutrition focuses on the interplay between food and health.
Signal transduction refers to movement of signals from outside the cell to inside the cell as well as the movement of signals within a cell.
Signal transduction can be initiated by the binding of ligands to membrane bound receptors or the entering of small molecules through the cell membrane. In the cellular environment signals are often propagated through phosphorylation events including kinases and phosphatases. Small molecules can also enter directly into the nucleus, effecting the activity of nuclear receptors that constitute a distinct class of transcription factors. The eventual outcome of signal transduction is an alteration in cellular activity and changes in the program of genes expressed within the responding cells.
Structural biology is concerned with the study of the architecture and shape of biological macromolecules, including proteins and nucleic acids.
The methods that structural biologists use to determine their structures include crystallography, NMR and electron microscopy. Molecular modeling is a complement whereby structures and interactions are modelled based on available knowledge. Bioinformatics can be used to look for patterns of sequences that give rise to particular shapes. In structural biochemistry, the relation between structure and function is investigated using various qualitative and quantitative assays in combination with structural determination.
Toxicology is the study of the adverse effects of chemicals on living organisms.
Virology is the study of viruses. It includes the molecular biology of virus replication; the structure of virus particles; the interactions between the virus and the host cell; the diseases that the virus causes in the host; viral epidemiology i.e. how the virus persists in nature and spreads from victim to victim; vaccination and drug treatment against virus; virus as vectors and viral evolution.