Research and group leaders

BioNut Research Areas

Functional genomics

Functional genomics involves making use of the vast amount of data produced by genomic projects such as genome sequencing with the aim of describing gene functions and interactions.

Functional genomics focuses on dynamic aspects such as gene transcription, translation, and protein-protein interactions. Functional genomics includes also function-related aspects of the genome itself such as mutation and polymorphism Functional genomics involves measurements of molecular activities, often using high-throughput technologies.

Functional genomics includes, but is not limited to, measurements of transcript levels (transcriptomics), protein levels (proteomics), metabolite levels (metabolomics), protein interactions and studies in model organisms and many other approaches. Bioinformatics is a critical component of functional genomics.

Nutrition

Research within nutrition focuses on the interplay between food and health.

Signal transduction

Signal transduction refers to movement of signals from outside the cell to inside the cell as well as the movement of signals within a cell.

Signal transduction can be initiated by the binding of ligands to membrane bound receptors or the entering of small molecules through the cell membrane. In the cellular environment signals are often propagated through phosphorylation events including kinases and phosphatases. Small molecules can also enter directly into the nucleus, effecting the activity of nuclear receptors that constitute a distinct class of transcription factors. The eventual outcome of signal transduction is an alteration in cellular activity and changes in the program of genes expressed within the responding cells.

Structural biology

Structural biology is concerned with the study of the architecture and shape of biological macromolecules, including proteins and nucleic acids.

The methods that structural biologists use to determine their structures include crystallography, NMR and electron microscopy. Molecular modeling is a complement whereby structures and interactions are modelled based on available knowledge. Bioinformatics can be used to look for patterns of sequences that give rise to particular shapes. In structural biochemistry, the relation between structure and function is investigated using various qualitative and quantitative assays in combination with structural determination.

Toxicology

Toxicology is the study of the adverse effects of chemicals on living organisms.

Virology

Virology is the study of viruses. It includes the molecular biology of virus replication; the structure of virus particles; the interactions between the virus and the host cell; the diseases that the virus causes in the host; viral epidemiology i.e. how the virus persists in nature and spreads from victim to victim; vaccination and drug treatment against virus; virus as vectors and viral evolution.

Research Group Leaders A-Z

Group Leader Research Group & Project
Karin Dahlman-Wright      ESR - estrogen signaling research group
Mauro D'Amato Molecular genetics of gastrointestinal disease
Patrick Cramer      Genome regulation
Carsten Daub Clinical transcriptomics
Karl Ekwall Epigenetics, chromatin remodelling and cancer
Maria Eriksson Searching for genetic mechanisms that affect aging
Henrik Garoff Activation of HIV-1 and murine leukemia virus
Jan-Åke Gustafsson Nuclear receptors in health and disease
Hans Hebert Cryo electron microscopy of membrane
proteins and biomolecular assemblies
Luca Jovine Structural studies of egg-sperm interaction
and human hedgehog signaling proteins
Maria Kasper Stem cell dynamics in skin - from homeostasis to cancer
Juha Kere Molecular genetics and biology of complex diseases
Marie Löf Early-life factors important for childhood obesity:
observational and interventional studies
Lennart Möller Analytical toxicology and clinical applications
Lennart Nilsson Simulating the behavior of proteins and nucleic acids
Sam Okret Effects of glucocorticoids and estrogens on cells
and functions of the immune system
Joseph Rafter Host-microbe interactions
Roger Strömberg Nucleic acids and peptides in biotechnology and therapy
Staffan Strömblad Cell biology of cancer
Peter Swoboda From the basic biology of cilia to ciliopathy
disease states in humans
Jussi Taipale Systems biology group
Rune Toftgård Hedgehog signalling, tissue stem cells
and cancer development
Eckardt Treuter Epigenomic control of metaflammation by
nuclear receptor-coregulator pathways
Peter Zaphiropoulos Dissecting Hedgehog Signaling - role of RNA-based mechanisms
Gene regulationGenomicsNutritionSignal transductionStructural BiologyToxicologyVirology