Seminar: Gli1+ MSC-like cells serve as progenitors of the vascular wall and drive vascular calcification in chronic kidney disease
Title: 'Gli1+ MSC-like cells serve as progenitors of the vascular wall and drive vascular calcification in chronic kidney disease'
Speaker: Dr. Christoph Kuppe
Division of Nephrology and Clinical Immunology, Medical Faculty RWTH Aachen University, Germany
Host: Eckardt Treuter, Department of Biosciences and Nutrition
The seminar will discuss the role of mesenchymal stem cell (MSC) therapy for kidney injury. Dr. Kuppe will in particular present recent studies demonstrating that expression of the hedgehog transcriptional activator Gli1 specifically marks perivascular MSC. Genetic fate tracing of MSC in kidney injury revealed their contribution to the myofibroblast pool whereas ablation of MSC reduced kidney fibrosis. Pharmacologically targeting Gli proteins inhibits cell-cycle progression of myofibroblasts in kidney fibrosis and is a promising therapeutic strategy in chronic kidney disease.
Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease.
Cell Stem Cell 2016 Nov;19(5):628-642
Role of mesenchymal stem cells in kidney injury and fibrosis.
Curr. Opin. Nephrol. Hypertens. 2016 Jul;25(4):372-7